分子印迹技术在药物缓释领域的研究进展  

Research Advances in the Application of Molecular Imprinting Technique in Drug Delivery

作　　者：阚文涛[1] 李欣[2] 蹇源[1] 胡睿[1] 魏洪源[1] 罗顺忠[1] 

机构地区：[1]中国工程物理研究院核物理与化学研究所,绵阳621900 [2]哈尔滨工业大学理学院,哈尔滨150001

出　　处：《材料导报》2014年第13期42-45,51,共5页Materials Reports

基　　金：国家自然科学基金(50878061;51103140);城市水资源与环境国家重点实验室课题(ESK200801)

摘　　要：分子印迹技术是制备对特定分子结构具特异性识别功能的聚合物的一项重要技术,其在药物缓释领域的应用越来越引起研究者们的重视。在介绍了分子印迹技术的概念及原理的基础上,提出了应用于药物传输领域的分子印迹聚合物所应当具备的特性,综述了近年来分子印迹技术在药物传输领域的研究进展。并指出:为提高聚合物作为药物载体的生物顺应性,在水相中对聚合物的合成、可控自由基聚合制备规格统一的聚合物及将分子印迹聚合物应用于智能医用材料领域将成为日后研究的主流。Molecular imprinting technique （MIT） is an important tool to product polymers with the ability to recognize and bind specific molecules, and its applications in the field of drug delivery are currently catching more and more attention from the researchers. In addition to the introduction of the concept and principle of MIT, the qualifica- tions that MIPs as drug delivery systems are indicated, and the researches on MIPs as drug delivery systems are re- viewed. Furthermore, it is revealed that in order to enhance the biocompatibility, polymer synthesis in water phase, controllable radical polymerization to produce similar polymers and the applications as auto-medical materials would be the mainstream in the future.

关 键 词：分子印迹技术 药物传输 聚合物 模板药物 释放 

分 类 号：O6-1[理学—化学]