蓝光杀菌效果及其机制研究进展  

Advances in the research on bactericidal effect of blue light and its mechanism

作　　者：王川[1] 杨鹏高[1] 王宁[1] 姚敏[1] 

机构地区：[1]上海交通大学医学院附属第三人民医院烧伤整形科,201900

出　　处：《中华烧伤杂志》2014年第3期258-261,共4页Chinese Journal of Burns

摘　　要：细菌感染已成为全球性问题，且细菌耐药情况越来越严重，因此，我们需要寻找一种新的、不会使细菌产生耐药性的杀菌方法，这一探索应该属于高度优先的研究和开发项^[1]。Blue light is commonly used to kill Propionibacterium acnes in clinic.Furthermore,blue light exhibits a good bactericidal effect against Helicobacter pylori,methicillin-resistant Staphylococcus aureus,Pseudomonas aeruginosa,and many oral bacteria in laboratory studies.The bactericidal mechanism of blue light as commonly accepted consists photo-excitation of intracellular porphyrins resulting in production of cytotoxic reactive oxygen species which can inactivate bacteria.Blue light can kill bacteria without additional exogenous photosensitizers.In addition,it produces little harm to mammalian cells.Therefore,as the increasing emergence of antibiotic resistant microorganisms,blue light might be a good antibacterial tool.

关 键 词：光疗法 灭菌 治疗结果 卟啉类 

分 类 号：R378[医药卫生—病原生物学]