耳鸣患者静息态MR的局部区域一致性研究  

Resting-State fMRI Regional Homogeneity in Tinnitus Patients

作　　者：杨海弟[1] 郑亿庆[1] 区永康[1] 黄夏茵[1] 

机构地区：[1]中山大学孙逸仙纪念医院耳鼻咽喉头颈外科,广州510120

出　　处：《中华耳科学杂志》2014年第2期203-206,共4页Chinese Journal of Otology

基　　金：国家自然科学基金(81170921);广东省自然科学基金(S2011010004576)

摘　　要：目的研究耳鸣患者静息态fMRI的区域一致性(regional homogeneity,Reho)值脑区功能及中枢网络连接特点,从神经影像学及功能连接方面进一步阐明耳鸣的中枢发病机制。方法对18例耳鸣患者与20例年龄、性别相匹配的健康人群的分别行静息态功能性核磁共振(fMRI)检查,分析比较其Reho值变化,再将异常脑区或听觉中枢做为种子点行功能网络连接,研究耳鸣患者的脑区及功能网络连接变化。结果 ReHo表现为耳鸣组>正常组的脑区有双侧额下回、右侧颞中回、双侧中央后回;耳鸣组<正常组的脑区有小脑半球。经FWE严格校正后耳鸣组比对照组增强的区域为额下回(FWE P<0.05)减弱的区域为小脑前叶(FWE P<0.05,cluster level)。以额下回IFG作为种子点行功能连接,发现对照组>耳鸣组的区域为中脑(FWE,P<0.001)及右腹侧纹状体(FWE P<0.05,Small volume correction)。结论耳鸣的fMRI结果显示耳鸣患者的听觉中枢及非听觉中枢均在耳鸣中起重要作用,中枢功能连接提示耳鸣患者听觉脑区丘脑、颞中回与边缘系统海马旁回、岛叶等存在功能连接是导致耳鸣发生发展的原因之一。[Objective]To study central functional network connections and their alterations in tinnitus patients using fMRI. Meth-ods fMRI was performed in 18 tinnitus patients and 20 controls. Regional consistency （regional homogeneity or ReHo value） and functional network connection alterations were compared between the tinnitus patients and controls. Results Tinnitus pa-tients showed increased ReHo values in gyrus frontalis inferior and decreased ReHo values in anterior lobe of cerebellum in comparison with the controls. The regions with decreased ReHo values were bilateral inferior frontal gyrus, middle frontal gy-rus and anterior cingulate. Conclusions Abnormal fMRI changes in auditory cortex and non-auditory cortex are present in tin-nitus patients. The severity of tinnitus is linearly correlated to the changes in some brain regions. fMRI may be useful in evalu-ating tinnitus.

关 键 词：耳鸣严重程度 THI FMRI ReHo值 功能连接 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]