黄芪多糖对小鼠B16-BL6黑色素瘤肺转移的影响  

Effects of Astragalus Polysaccharides on B16-BL6 Melanoma Lung Metastasis in Mice

作　　者：赵勇 张璐[2] 蔡丽萍[2] 徐晨[2] 

机构地区：[1]上海实验动物研究中心,上海201203 [2]第二军医大学实验动物中心,上海200433

出　　处：《实验动物与比较医学》2014年第3期232-234,241,共4页Laboratory Animal and Comparative Medicine

基　　金：上海市科技发展基金项目（No.12140900200）资助

摘　　要：目的 探讨不同剂量的黄芪多糖对小鼠B 16-BL6黑色素瘤肺转移的影响及机制.方法 采用B 16-BL6小鼠人工肺转移模型研究不同剂量黄芪多糖对黑色素瘤肺转移的影响;测量给药后小鼠免疫器官指数的变化探讨其可能的机制.结果 高剂量组的黄芪多糖能够显著抑制小鼠B16-BL6黑色素瘤肺转移,并能增加小鼠脾脏指数.结论 高剂量黄芪多糖可能通过增强免疫达到抗黑色素瘤细胞肺转移的作用.Objective To explore the effect and mechanism of different doses of astragalus polysaccharides on pulmonary metastasis of B 16-BL6 melanoma in mice.Methods The B 16-BL6 artificial pulmonary metastasis model was used to study the influence of different doses of astragalus polysaccharides on pulmonary metastasis of melanoma; exploring its possible mechanism by measuring the immune organ index variation after administration in mice.Results High dose of astragalus polysaccharide can significantly inhibit B 16-the BL6 melanoma lung metastasis and increase the index of spleen in mice.Conclusion High dose of astragalus polysaccharides maybe inhibited the pulmonary metastasis of melanoma cells by enhancing immunity.

关 键 词：B16-BL6细胞 黄芪多糖 肺转移 黑色素瘤 

分 类 号：R285.5[医药卫生—中药学]