基因及其顺式调控元件在动物表型进化中的作用  

Role of genes and their cis-regulatory elements during animal morphological evolution

作　　者：孙博渊 涂剑波[1] 李英[1] 杨明耀[1] 

机构地区：[1]四川农业大学动物遗传育种研究所,成都611130

出　　处：《遗传》2014年第6期525-535,共11页Hereditas（Beijing)

基　　金：四川农业大学"双支"计划基金(编号2920200);四川省教育厅"科研创新团队"基金资助

摘　　要：顺式调控假说是当前进化发育生物学中重要的理论之一,该假说认为顺式调控元件的进化是调控外表性状进化的主要遗传机制。然而越来越多的实验结果表明,仅靠顺式调控假说远不足以解释复杂的进化发育过程,其他因素也会导致表型的进化,如:与顺式调控元件相联基因的蛋白序列改变;基因及染色体组复制;蛋白结构域与顺式调控元件的灵活性等。文章回顾了近年来顺式调控元件以及与顺式调控元件相联基因的进化发育研究,探讨了进化发育生物学研究的新方法与新思路。Cis-regulatory hypothesis is one of the most important theories in evolutionary developmental biology （evo-devo）, which claims that evolution of cis-regulatory elements （CREs） plays a key role during evolution of morphology. However, an increasing number of experimental results show that cis-regulatory hypothesis alone is not far enough to ex-plain the complexity of evo-devo processes. Other modifications, including mutations of protein coding, gene and genome duplications, and flexibility of homeodomains and CREs, also cause the morphological changes in animals. In this review, we retrospect the recent results of evolution of CREs and genes associated with CREs and discuss new methods and trends for research in evo-devo.

关 键 词：进化发育生物学 顺式调控元件 基因 外表性状 

分 类 号：Q78[生物学—分子生物学]