小双节RNA病毒感染与腹泻相关性的Meta分析  

The relationship between picobirnavirus infection and diarrhea: Meta-analysis

作　　者：赵德坚[1,2] 张海龙[2] 滕勇勇[1] 黄韵[1,2] 胡贵方[1] 何雅青[2] 

机构地区：[1]南方医科大学公共卫生与热带医学学院流行病学系,广东广州510515 [2]深圳市疾病预防控制中心,广东深圳518055

出　　处：《热带医学杂志》2014年第5期651-655,共5页Journal of Tropical Medicine

摘　　要：目的对小双节RNA病毒（PBV）与腹泻相关性进行Meta分析，探讨PBV感染是否为腹泻的危险因素。方法计算机检索MEDLINE、Google Scholar、EMBASE、CBM、万方、CNKI电子数据库，检索时限为1988—2013年。纳入所有研究小双节RNA病毒与腹泻相关性的配对或非配对的病例对照研究，采用RevMan5．2和CMAv2软件为纳入文献进行Meta分析，并进一步进行异质性检验、敏感性分析及偏倚评估。结果纳入9篇文献中（病例组2576例，对照组1916例），普通人群2篇、HIV感染者4篇、儿童3篇。结果提示病例组与对照组的PBV感染率差异有统计学意义（OR=3．54，95％CI：2．13—5．88，P〈0．00001，F=0．21％），敏感性分析提示结果稳定，漏斗图表明发表偏倚小。结论PBV与腹泻存在相关性，在HIV感染人群和儿童群体中存在相关性，且儿童比HIV感染者的相关性更密切（OR=5．53〉3．41）。Objective To conduct a meta-analysis of case-control studies for assessing association between picobirnavirus （PBV）and diarrhea in order to explore whether PBV infection is the risk factor for diarrhea. Methods MEDLINE,Google Scholar,Wangfang and CNKI database with the time limit of 1988 to 2013 were searched.Meta-analyses were performed by RevMan 5.2 and CMA v2 software for all of case-control studies for assessing association between PBV and diarrhea after strict screening. Heterogeneity test, sensitivity analysis and publication bias assessment were also performed. Results Nine case-control studies（2 576 patients and 1 916 controls） were included.According to the difference of object types, all of included studies were divided to three groups （population group, children group and HIV infected group）. Heterogeneity test demonstrate low degree of heterogeneity （F=0.21%） between PBV infection and diarrhea in included studies. The pooled OR was 3.54（95%CI： 2.13-5.88 ;P〈0.000 01 ）.Sensitivity analysis suggested the results of meta-analysis were reliable. The funnel plot suggested that the publication bias is acceptable. Conclusion There is correlation between PBV infection and diarrhea, association between PVB infection and diarrhea in children group is significant and seems higher than in HIV infected group. Relation between PBV and diarrhea needs to be further confirmed by future large sample and prospective investigations.

关 键 词：小双节RNA病毒 腹泻 HIV感染 儿童 META分析 

分 类 号：R512.5[医药卫生—内科学]