肾血管性高血压患者血压变异性及靶器官损害的临床研究  

Clinical Study on Patients with Renal Vascular Hypertension Blood Pressure Variability and Target Organ Damage

作　　者：王雪芬[1] 

机构地区：[1]邯郸市第二医院内一科,邯郸056000

出　　处：《中国医药导刊》2014年第4期565-566,568,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨肾血管性高血压血压变异性及靶器官相关影响。方法:选取我院收治的高血压患者共72例患者作为研究对象,根据肾动脉造影结果,将其分为两组,其中肾血管狭窄组(RVH)34例,原发性高血压组(PH)组38例,完成体格检查、生化检查、心脏彩超、动态血压监测,并获取血流动力学指标,对各项指标结果进行统计学分析。结果:两组患者在多种心血管危险因素等指标水平比较,差异无统计学意义(P>0.05);在白昼平均舒张压、白昼平均动脉压、夜间平均舒张压、夜间平均动脉压、24h平均舒张压、24h平均动脉压、24h平均舒张压及24h收缩压标准差比较,RVH组显著高于PH组,差异有统计学意义(P<0.05);RVH组患者中出现非勺型血压节律比例显著高于HP组(70.5%比42.1%,P=0.015),差异有统计学意义(P<0.05)。RVH组患者左室肥厚发生率高于PH组(70.5%比394%,P=0.008),其差异有统计学意义(P<0.05)。结论:肾血管性高血压患者血压变异性大,血压本身又反过来加重肾脏本身病变,更容易引发靶器官的损害,临床医师应给予重点关注。Objective：To study the renal vascular hypertension blood pressure variability and target organ effects. Methods：A total of 72 cases of patients with hypertension in our hospital were selected as the research object, according to the results of renal artery angiography, the patients were divided into two groups, one group of renal artery stenosis （RVH） in 34 cases, primary hypertension group （PH group） 38 cases, complete physical examination, biochemical examination, echocardiography, dynamic blood pressure monitoring, and obtain the hemodynamics index, statistical analysis of all outcome measures. Results：Compared two groups of patients with multiple cardiovascular risk factors and index level, no significant difference （P〉0.05）; in the daytime mean diastolic pressure, mean arterial pressure, day and night average diastolic blood pressure, mean arterial pressure, 24h night mean diastolic pressure, mean arterial pressure of 24 h, 24 h and 24 h, the average diastolic blood pressure systolic blood pressure standard deviation;non-dipper rhythm of blood pressure in proportion of patients in the RVH group was significantly higher than that in HP group （70.5%vs 42.1%, P=0.015）. Left ventricular hypertrophy in cases of patients in the RVH group number proportion is higher than that of PH group （70.5% vs 394%, P=0.008）. Conclusion：Patients with renal vascular hypertension blood pressure variability, blood pressure itself in turn aggravate renal lesion, more easily lead to target organ damage, clinicians should focus on.

关 键 词：高血压病 肾血管性高血压 动态血压 变异性 

分 类 号：R544.1[医药卫生—心血管疾病]