醛固酮拮抗剂治疗高血压病患者左心室舒张功能不全的研究  

Aldosterone Antagonists in the Treatment of Essential Hypertensive Patients with Left Ventricular Diastolic Dysfunction

作　　者：罗卉[1] 

机构地区：[1]四川省广元市第二人民医院心血管内科,广元628017

出　　处：《中国医药导刊》2014年第4期673-674,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨醛固酮拮抗剂治疗高血压病患者左心室舒张功能不全的临床效果。方法:随机选取我院2011年1月至2012年12月间高血压合并左心室舒张功能不全患者62例随机分组,对照组31例采用常规治疗,研究组31例在此基础上加用醛固酮拮抗剂口服用药。结果:治疗后两组血压和心率均较治疗前有明显下降(P<0.05),但治疗后两组数据无统计学意义(P>0.05);两组治疗后EV较治疗前明显升高、AV明显下降、E/A明显升高,且治疗后研究组EV、AV和E/A较对照组改善效果更好(P<0.05)。结论:醛固酮拮抗剂应用于高血压患者左心室舒张功能不全具有积极作用。Objective：To investigate the treatment of essential hypertensive patients with left ventricular diastolic dysfunction and the clinical effect of aldosterone antagonist. Methods：Randomly selected in our hospital from 2011 January to 2012 December in hypertensive patients with left ventricular diastolic dysfunction in 62 patients were randomly divided into two groups, 31 cases in the control group with conventional therapy, 31 cases of the study group based on the use of aldosterone antagonists oral medication. Results：Rhe two groups after the treatment, the blood pressure and heart rate of patients have significantly decreased （P〈0.05）, but the two groups after the treatment, the data was not statistically significant （P〉0.05）;the two group after treatment than before treatment significantly increased EV, AV decreased significantly, E/A increased significantly after treatment, and EV of the study group compared with the control, AV and E/A group improved better （P〈0.05）. Conclusion：The application of aldosterone antagonists in patients with hypertension left ventricular diastolic dysfunction plays a positive role.

关 键 词：醛固酮拮抗剂 高血压 左心室舒张功能不全 临床研究 

分 类 号：R541.6[医药卫生—心血管疾病] R544.1[医药卫生—内科学]