腹膜透析对肾衰竭患者血清hs-CRP、IL-6、TNF-α及Alb水平的影响  

The Effect of Peritoneal Dialysis on the hs-CRP、IL-6、TNF-α and Alb of Renal Failure Patients

作　　者：赵黎[1] 张任[1] 

机构地区：[1]湖北医药学院附属东风医院肾内科,十堰442008

出　　处：《中国医药导刊》2014年第5期775-776,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨腹膜透析对肾衰竭患者的血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、α肿瘤坏死因子(TNA-α)和血清白蛋白(Alb)水平的影响。方法:选取我院收治的肾衰竭患者29例作为观察组,同期体检的健康体检者30例作为对照组,抽血检查hs-CRP、IL-6、TNF-α和Alb,比较透析前后各指标的变化。结果:(1)透析前患者hs-CRP、IL-6、TNF-α显高于对照组、Alb低于对照组(P<0.05)。透析后hs-CRP、IL-6、TNF-α较透析前降低、Alb升高(P<0.05)。(2)Alb与hs-CRP、IL-6、TNF-α分别呈负相关(P<0.05)。结论:肾衰竭患者存在明显的炎症反应和营养不良,而腹膜透析在一定程度上能够降低患者的炎症反应,但患者仍存在炎症反应,需提高重视,同时此类患者需注意营养问题,以提高患者生命质量。Objective：To investigate the effect of peritoneal dialysis on the hs-CRP、IL-6、TNF-αand Alb of renal failure patients.Methods：In our hospital, 29 patients with renal failure were the observation group, the 30 cases of healthy volunteers were the control group,the serum hs-CRP, IL-6, TNF-αand Alb were compared before and after dialysis changes.Results：（1） The hs-CRP, IL-6, TNF-αof patients pre-dialysis were higher than the control group, Alb lower than the control group （P〈0.05）. After dialysis, hs-CRP, IL-6, TNF-αdecreased compared with pre-dialysis, Alb increased （P〈0.05）. （2） There were negatively correlated between Alb and hs-CRP, IL-6, TNF-α（P〈0.05）.Conclusion：The renal failurepatients has Inflammation and malnutrition.The peritoneum can reduce the inflammatory response, but patients still has inflammation so we need to improve attention on it. While such patients should pay attention to nutritional issues in order to improve the quality of life of patients .

关 键 词：腹膜透析 肾衰竭 超敏C反应蛋白 白细胞介素-6 Α肿瘤坏死因子 血清白蛋白 

分 类 号：R692.5[医药卫生—泌尿科学]