曲美他嗪联合地尔硫卓对稳定型心绞痛的疗效研究  

Study on Efficacy of Trimetazidine Combined Diltiazem on Stable Angina

作　　者：王才阳[1] 李现峰[2] 

机构地区：[1]山东省临朐县人民医院心内一科,临朐262600 [2]山东省临朐县人民医院产一科,临朐262600

出　　处：《中国医药导刊》2014年第5期828-829,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨曲美他嗪联合地尔硫卓治疗稳定型心绞痛临床效果。方法:从我院在2012年7月到2013年7月期间收治的稳定型心绞痛患者中抽取118例进行回顾性分析,依照随机数字表的方式给予其中59例患者常规治疗(乙组),另59例患者采用曲美他嗪+地尔硫卓联合治疗(甲组),对两组的临床效果进行对比,并观察心绞痛发生情况。结果:经相应治疗,在总有效率上,甲组为91.53%(54/59),乙组为78%(46/59),甲组显著高于乙组(P<0.05);与治疗前相比,两组在治疗后的心绞痛发作次数以及持续时间上均减少,在减少幅度上,甲组要显著优于乙组(P<0.05)。结论:针对稳定型心绞痛患者,运用曲美他嗪+地尔硫卓联合治疗能够起到显著效果,可以使患者的运动耐受量得到明显改善,并使心绞痛发作次数和持续时间得到减少与降低,安全无毒副作用,值得推广。Objective：To investigate the clinical effect of trimetazidine combined with diltiazem in treatment of stable angina pectoris. Methods：118 cases selected from our hospital in treatment of stable angina pectoris were retrospectively analyzed from July 2012 to July 2013, in accordance with the manner in which the random number table, 59 patients in conventional treatment （Group B）, and the other 59 cases were treated with trimetazidine＋diltiazem combination therapy （Group A）, the clinical effect of the two groups were compared, and observed the occurrence of angina. Results：After treatment, the total efficiency, Group A was 91.53%（54/59）, Group B was 78%（46/59）, Group A was significantly higher than Group B （P〈0.05）;former and treatment compared, both groups to reduce the number of attacks of angina after treatment and the duration on reducing the amplitude Group A was significantly better than Group B （P〈0.05）.Conclusion：For patients with stable angina, the use of trimetazidine＋diltiazem combination therapy can play a significant effect, can make the motion tolerance of patients improved significantly, and to angina attack frequency and duration gets reduced and reduced, safe side effects, it is worth promoting.

关 键 词：曲美他嗪 地尔硫卓 稳定型心绞痛 临床疗效 

分 类 号：R541.4[医药卫生—心血管疾病]