盐酸戊乙奎醚在无痛人工流产中的应用  

Application of penehyclidine in painless induced abortion

作　　者：杨明[1] 杨岩[2] 郝鹏锴 管晓丽[1] 

机构地区：[1]吉林省妇幼保健院,130000 [2]吉林大学第一医院

出　　处：《中国实用医药》2014年第14期21-22,共2页China Practical Medicine

摘　　要：目的观察戊乙奎醚术前应用于无痛人工流产的临床结果。方法选择22-35岁女性患者1200例（ASA I-Ⅱ级）。随机分配成A、B两组,A组为对照组（600例）术前30 min肌内注射1 ml注射用水,B组为戊乙奎醚组（600例）,患者术前30 min肌内注射戊乙奎醚0.5 mg。测定30 min唾液分泌量,用视觉模拟评分（VAS）方法测定口干程度,记录不良事件。结果给药30 min,A、B两组唾液分泌量分别较用药前变化（2.88±19.51）mg,（-21.30±20.32）mg,其B组用药前后唾液分泌量的下降差异有统计学意义（P〈0.05）;VAS评分,B组用药前后明显增加;给药30 min,两组心率变化较用药前无明显变化,两组用药前后变化差异无统计学意义（P〈0.05）。观察期间无严重不良反应。术中牵扯宫颈时两组心率变化（-27.72±6.90）,（4.32±7.20）bpm,两组差异有统计学意义（P〈0.05）。结论戊乙奎醚作为全麻术前用药,可明显减少唾液分泌,无心率增,无明显不良反应,使用安全。ObjectiveTo observe the clinical effect of penehyclidine in painless induced abortion. Methods1200 female patients （ASA I-II）aged 22-35 years were randomly divided into group A and group B. Group A were the control groups （600 cases）, water for injection 1 ml intramuscular injection within 30 minutes before operation.Group B were penehyclidine group （600 cases）, penehyclidine 0.5 mg intramuscular injection within 30 minute before operation. Measuring the salivary secretory volume in 30 min. Using visual analogue score （VAS） method to measure mouth dryness. Recording the adverse events.Results 30 minutes after administration, the salivary secretory volume of group A and group B respectively compared with those before treatment were changing （2.88±19.51）mg, （-21.30±20.32）mg. The decrease of salivary secretion was of statistical significance before and after the treatment in group B （P〈0.05）. VAS score was significantly increased after the treatment in group B. After 30 minutes of administration, there was no obvious change of heart rate compared with before treatment in two groups. Differences of two groups were not of statistical significance after the treatment （P〈0.05）. There were no severe adverse reactions in the observation. The heart rate of the two groups changed by （-27.72± 6.90）, 4.32±7.20） bpm because of intraoperative involved cervical. There was of statistical significance （P〈0.05） in two groups.ConclusionPenehyclidine hydrochloride as premedication of general anesthesia can reduce the salivary secretion obviously, without increasing heart rate and obvious adverse reaction and can be used safely.

关 键 词：戊乙奎醚 唾液分泌 无痛人工流产 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]