汽化电切联合内分泌疗法治疗老年晚期前列腺癌临床观察  

Electrovaporization joint with endocrine therapy to treat senile advanced prostate cancer

作　　者：刘尧 颜伟[2] 

机构地区：[1]北京市延庆县医院外三科,北京102100 [2]复旦大学附属中山医院青浦分院泌尿外科,上海201700

出　　处：《中国性科学》2014年第6期59-61,共3页Chinese Journal of Human Sexuality

摘　　要：目的:探讨汽化电切联合内分泌疗法治疗老年晚期前列腺癌的临床效果。方法:选择2008年2月至2009年2月我院收治的老年晚期前列腺癌患者48例(研究组),对其采用经尿道前列腺汽化电切术,病理确诊为前列腺癌后加行双侧睾丸切除术;对照组行常规治疗,每2个月交替口服氟他胺、康士得的联合内分泌疗法,比较术后两者相关指标的变化。结果:两组手术时间、切除前列腺重量、术后2年及以下和2年以上生存率、死亡率比较,差异均有显著意义(P<0.05)。与对照组相比,研究组血清PSA、IPSS分、残余尿量均下降,尿流率、膀胱压力均升高,差异有高度统计学意义(P<0.01或P<0.001)。结论:对老年晚期前列腺癌患者行经尿道前列腺汽化电切术,能解除下尿路梗阻,联合内分泌疗法明显抑制肿瘤生长而延长生命,提高患者生活质量。Objectives：To explore the clinical efficiency of electrovaporization joint with endocrine therapy for treatment of elderly advanced prostate cancer.Methods：48 elderly patients with advanced prostate cancer （re-search group）in our hospital in February 2008 to February 2009 were chosen and given transurethral electrovapor-ization of prostate,with pathological diagnosis as bilateral orchiectomy with prostate cancer,while the control group received routine treatment-endocrine therapy by orally taking flutamide and Casodex alternately every 2 months. Changes of relevant indicators after treatment were compared.Results：The operation time,weight of prostate ab-scised,postoperative survival rates and mortality both within 2 years and above 2 years of the two groups were com-pared;differences were significant （P〈0.05）.Compared with the control group,the serum PSA,IPSS,residual urine volume decreased while urine flow rate and bladder pressure increased,demonstrating significant difference （P〈0.01 or P〈0.001 ）.Conclusion：Transurethral electrovaporization of prostate for elderly patients with ad-vanced prostate cancer can remove the lower urinary tract obstruction,and joint treatment with endocrine therapy can significantly inhibit tumor’s growth and prolong human life as well as improve life quality.

关 键 词：前列腺癌 前列腺切除术 双侧睾丸切除术 内分泌疗法 老年 

分 类 号：R699.8[医药卫生—泌尿科学]