磷酸钙与胶原双相多级仿生骨组织工程支架研究  

Calcium Phosphate and Collagen Biphasic Multi-layer Biomimetic Scaffolds for Bone Tissue Engineering

作　　者：周长春[1] 樊渝江[1] 谭言飞[1] 刘丽[2] 董志红[2] 张兴栋[1] 

机构地区：[1]四川大学国家生物医学工程研究中心,四川成都610064 [2]成都大学工业制造学院,四川成都610106

出　　处：《成都大学学报（自然科学版）》2014年第2期101-105,共5页Journal of Chengdu University（Natural Science Edition）

基　　金：国家自然科学基础研究计划(2011CB606201)资助项目

摘　　要：磷酸钙与胶原是天然骨组织的重要组成成分,介绍了一种仿生设计磷酸钙与胶原双相复合的多级仿生骨组织支架.采用双氧水发泡技术精确定制磷酸钙支架孔结构,结合真空灌注胶原以及仿生矿化技术,构建磷酸钙,胶原双相多级仿生骨组织支架,材料的孔结构及化学组分可实现定制设计.通过对支架材料测试表征,结果显示,这种无机/有机/无机多级仿生支架材有良好的力学性能.材料的体外细胞实验结果证实,这种多级仿生支架材料具有良好的生物相容性.Calcium phosphate and collagen are the important components of natural bone tissue. In this paper, a bionimetic design of calcium phosphate and collagen biphasic multi - layer scaffold is presented. This study uses the hydrogen peroxide foaming technology to accurately tailor the porous structure of scaf- fold. Combined with vacuum infusion of collagen and biomimetic mineralization, this paper builds the calci- um phosphate and collagen multi-layer bionimetic bone tissue scaffolds. The porous structure and chemical composition of the material can be customized. The scaffold characterization test results show that this inor- ganic/organic/inorganic multi-layer bionic scaffold has good mechanical properties. In vitro cell culturing re- suits confirm that this biomimetic scaffold material has good biocompatibility, which is expected to be used for bone defect repair.

关 键 词：磷酸钙 胶原 骨组织工程支架 仿生结构 骨髓间充质干细胞 

分 类 号：R318.08[医药卫生—生物医学工程]