大黄素结合黄皮酰胺治疗老年痴呆症的临床效果研究  

Clinical research on treating Alzheimer's disease with emodin and clausenamide

作　　者：程耀南 吴洁 

机构地区：[1]高州市中医院,广东高州525200

出　　处：《中医临床研究》2014年第14期70-71,共2页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨大黄素结合黄皮酰胺治疗老年性痴呆的临床疗效。方法:将2012年6月-2013年1月在我院脑病科治疗的87例老年痴呆患者作为研究对象。随机分为对照组43例和治疗组44例。对照组给予多奈哌齐治疗;治疗组给予大黄素加黄皮酰胺治疗。观察两组患者治疗半年后的认知能力、词汇记忆能力、Blessed痴呆量表评分情况及精神行为症状的变化。结果:①治疗组患者的认知功能评分、词汇记忆评分及Blessed痴呆量表评分,都优于对照组,差异具有统计学意义(P<0.01)。②精神行为症状方面,治疗组患者的精神病评估量表及日常生活能力量表评分均低于对照组患者,差异具有显著意义。结论:大黄素联合黄皮酰胺能有效改善老年痴呆患者的精神行为症状,提高认知能力及记忆力,值得临床推广运用。Objective： To study the clinical efficacy of emodin and clausenamide on treating Alzheimer’s disease. Methods： 87 patients were randomly divided into two groups. The control group was given donepezil; another was given emodin and clausenamide. Results：①Patients’cognitive function score, vocabulary memory score and Blessed dementia scale in treatment group were better, and the differences were statistically significant （P〈0.01）.②Patients’ scale score of psychiatric and daily life ability in treatment group were lower, differences were statistically significant. Conclusion： Emodin and clausenamide can improve behavioral and psychological symptoms, enhance the cognitive ability and memory, is worthy of clinical promotion.

关 键 词：老年痴呆 大黄素 黄皮酰胺 Blessed痴呆量表 

分 类 号：R339[医药卫生—人体生理学]