中老年人体测量学指标与动脉硬化指标的关系  

Correlation between anthropometric parameters and arteriosclerosis biomarker in the middle-aged and the elderly

作　　者：刘严[1] 齐丽彤[2] 马为[2] 杨颖[2] 孟磊[2] 张宝娓[2] 霍勇[2] 

机构地区：[1]清华大学玉泉医院急诊科,北京100049 [2]北京大学第一医院心内科,北京100034

出　　处：《北京大学学报（医学版）》2014年第3期455-459,共5页Journal of Peking University:Health Sciences

摘　　要：目的：探讨中老年人人体测量学指标与动脉硬化指标之间的相关性。方法：选择北京市石景山区接受横断面调查的中老年居民1626人，年龄45～90岁，平均年龄（61．60±10．22）岁，分为健康组、高血压组和糖尿病组。由专人测量受试者身高、体重、腰围（waist circumference，WC）等指标，计算出腰身指数（waist to height ratio，WHtR）和体质量指数（body mass index，BMI）。采用无创检测设备分别测量反射波增强指数（augmentation index，AI）、踝脉搏波传导速度（brachial-ankle pulse wave velocity，baPWV）、踝臂指数（ankle-brachial index，ABI）、颈动脉内-中膜厚度（ intercellular membrane thickness ，IMT）等动脉硬化指标，分析各项指标间的相关性。结果：中心型肥胖者（男性WC＞85 cm、女性WC＞80 cm或WHtR＞0．5）和肥胖者（BMI＞28 kg/m2）百分比在高血压组和糖尿病组之间差别不显著（P＞0．05），但均显著高于健康组（P＜0．01）。 BMI与中心型肥胖测量指标WC和WHtR呈中度正相关（r分别为0．710和0．716）。在健康组，人体测量学指标（WC和WHtR）与baPWV、IMT和ABI呈正相关，与AI75呈负相关；BMI与IMT呈正相关，与AI75呈负相关，与baPWV和ABI不相关。糖尿病组BMI与baPWV呈负相关；高血压组BMI与baPWV、AI75呈负相关，WC与AI75呈负相关。 baPWV与人体测量学指标的一元线性回归分析结果显示，baPWV与WHtR回归直线方程为y＝0．949＋1．379x（R2＝0．046，P＜0．001），baPWV与WC回归直线方程为y＝1．133＋0．006x（R2＝0．027，P＜0．001）；baPWV与BMI不具有线性相关关系（P＝0．62）。结论：WHtR和WC预测动脉硬化优于BMI，中心型肥胖的人体测量学指标可作为心血管风险的预测因子。Objective：To investigate the correlation between anthropometric indices and arteriosclerosis detection indicators in the middle-aged and the elderly .Methods： A cross-sectional descriptive study was made of 1 626 individuals （ diabetics patients 23.37%, hypertensive subjects 39.48% and healthy individuals 37.15%）, aged 45 to 90 years [mean age：（61.60 ±10.22） years）] in Shijingshan Dis-trict, Beijing.Their measurements：body mass index （BMI）, waist circumference （WC）, and waist to height ratio （ WHtR ） .Arterial stiffness was assessed according to brachial-ankle pulse wave velocity （baPWV）, intima-media thickness （IMT）, augmentation index （AI） and ankle-brachial index （ABI）, which were measured by noninvasive detectors and equipment .The correlations between the various indi-cators were analyzed .Results：The percentages of the hypertensive and diabetic groups of central obesity （ male WC〉85 cm, female WC 〉80 cm or WHtR〉0.5 ） and of general obesity （ BMI〉28 kg/m2 ） were significantly higher than those of the healthy group （ P〈0 .01 ） .The difference between the two disease groups was not significant （ P〉0 .05 ） .There was a moderate positive correlation between the measures of abdominal obesity （WHtR and WC） and the general obesity indicators （BMI） （r=0.710 and 0.716） .In the healthy group , WC and WHtR showed positive correlation with baPWV , IMT and ABI, and negative correlation with AI 75 .BMI showed positive correlation with IMT and negative correla-tion with AI75 , and no correlation with baPWV and ABI .There was negative correlation between BMI and baPWV in the diabetic group .In the hypertension group , we found negative correlation between BMI and baPWV, maximum IMT, AI75 , and also between WC and AI 75 .The simple regression straight line of baPWV versus the anthropometric parameters showed that the regression equations were y =0 .949 ＋1.379 x （baPWV vs.WHtR, R2 =0.046, P〈0.001） and y=1.133＋0.006x （baPWV vs.

关 键 词：人体测量术 肥胖症 动脉硬化 

分 类 号：R589.25[医药卫生—内分泌]