RNA修复研究进展  

The Current Progress of RNA Repair

作　　者：李伟[1] 苏泽红[1] 杨杰[1] 何淑雅[1] 

机构地区：[1]南华大学生物化学与分子生物学研究所,衡阳421001

出　　处：《生物化学与生物物理进展》2014年第6期525-531,共7页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目(81272993)~~

摘　　要：机体DNA损伤修复的机制目前已研究得比较全面,而RNA损伤修复的研究却没有引起广泛的认识.主要由于人们长期以来认为损伤的RNA会被机体特异性降解而不是修复.近年来,随着多个RNA损伤修复系统的相继发现,揭示机体对损伤RNA可能优先选择进行修复.本文从噬菌体型RNA修复系统、细菌型RNA修复系统、酵母型RNA修复系统和人类的RNA损伤修复系统四个方面对目前RNA损伤修复研究的最新进展做一综述.The mechanism of the organism to repair DNA damage has been studied in reasonable detail. In contrast, the agents of damage to DNA also cause RNA damage have not been widely recognized. This is mainly due to aberrant RNAs are generally assumed to be degraded rather than repaired. With the discovery of RNA repair systems, the RNA damage of the organism may preferentially be repaired. Based on the latest findings, the phage-type RNA repair system, bacterial-type RNA repair system, yeast-type RNA repair system and human RNA damage repair system are reviewed and discussed in this paper.

关 键 词：RNA损伤 RNA修复 Pnkp HeM hABH3 

分 类 号：Q71[生物学—分子生物学] Q522