高纯间三氟甲基苯胺开发  

The Manufacture of m-(Trifluoromethyl)aniline

作　　者：许丹倩[1] 徐振元[1] 陈静华 卜鲁周 韩经龙 

机构地区：[1]浙江工业大学,杭州310014 [2]东阳市化工二厂,东阳322109

出　　处：《农药》2001年第1期9-12,14,共5页Agrochemicals

摘　　要：在对文献报道的间三氟甲基苯胺合成路线进行试验和分析对比的基础上 ,开发了以甲苯为起始原料 ,经催化氯化和氟化、变温硝化、低压液相催化加氢还原和精馏提纯生产含量达 99%以上的间三氟甲基苯胺新工艺 ,以甲苯计总收率为 73.1%。A process for the manufacture of m-(trifluoromethyl)aniline by catalytic chlorination of toluene, followed by catalytic fluorination in liquid phase , nitration, and hydrogenation in the presence of Raney Ni was described. The total yield was 73.1% and the purity of the product was 99% over.

关 键 词：间三氟甲基苯胺 中间体 合成 农药 水解法 氨化法 

分 类 号：TQ45[化学工程—农药化工]