骨代谢紊乱与糖尿病：有价值的防治并举  

Diabetes mellitus and bone metabolic disorders: valuable prevention and treatment

作　　者：亢晨 张斌[1] 孙瑶[2] 

机构地区：[1]哈尔滨医科大学附属第二医院口腔科硬组织发育和再生实验室,黑龙江省哈尔滨市150086 [2]同济大学附属口腔医院,上海市200072

出　　处：《中国组织工程研究》2014年第20期3263-3268,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81170960);国家重大科学仪器设备开发专项(2011YQ04008708)~~

摘　　要：背景:糖尿病能引起患者的骨代谢紊乱,导致骨质疏松和低创伤性骨折等骨相关疾病的发生,目前其致病机制还不是十分清晰。目的:将糖尿病导致骨代谢紊乱机制的最新进展作一综述,为糖尿病骨病的预防和治疗提供理论基础。方法:由第一作者电子检索2000年1月至2013年12月Pubmed数据库(http://www.ncbi.nlm.nih.gov/pubmed/)有关糖尿病对骨代谢调节作用的文章,英文检索词为"diabetes mellitus,bone"。文献内容需针对性强、具有代表性,排除重复性研究及单向性研究。结果与结论:初始检索6 979篇文献,按纳入排除标准筛选后,选出58篇文献进行综述。结果显示,尽管1型糖尿病和2型糖尿病对于骨密度影响不完全相同,但其最终都会导致骨质变脆、低创伤性骨折的可能性加大。原因在于高糖打破了成骨与破骨的平衡,使得破骨相对大于成骨,破骨细胞数量增加,与成骨相关的细胞因子受到抑制,随之而来的是骨密度降低,骨质变脆,骨折易感性显著增加。BACKGROUND：Diabetes mel itus can give rise to bone metabolic disorders in patients, resulting in the occurrence of osteoporosis and low traumatic fractures. However, the pathogenesis mechanism remains unclear. OBJECTIVE：To review the current research progress in the bone metabolic disorders resulting from diabetes mel itus, and to provide theoretical basis of the prevention and treatment of diabetic osteopathy. METHODS：A computer-based online search was conducted in Pubmed database （http：//www.ncbi.nlm.nih.gov/pubmed/） from January 2000 to December 2013. Articles focusing on diabetes mel itus regulating bone metabolism were col ected using the key words of“diabetes mel itus;bone”in English. High-quality relevant studies were included, while repetitions and unidirectional studies were excluded. RESULTS AND CONCLUSION：A total of 6 979 articles were obtained initial y, and after screening procedures 58 literatures were selectively included in this review. Although type 1 and type 2 diabetes mel itus exert different effects on the bone mineral density, they ultimately result in osteoporosis and low traumatic fractures. It is widely believed that the pathogenesis may be that high glucose breaks the balance between bone formation and bone absorption, so that bone absorption is greater than bone formation. The number of the osteoclasts is increased, while the cytokines of promoting osteogenesis are restrained. As a consequence, those result in low bone mineral density, brittle bone and high incidence of fracture.

关 键 词：组织构建 骨组织构建 糖尿病 糖尿病性骨病 骨质疏松 骨折 骨代谢 成骨细胞 破骨细胞 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]