表面预处理对镁铝水滑石结构性质和缓释性能影响  

Effects of Surface Pretreatment on Structure and Release Performances of Mg-Al Hydrotalcites

作　　者：黄清军[1] 廖梦尘[1] 曾虹燕[1] 张伟[1] 张治青[1] 刘小军[1] 李会[1] 

机构地区：[1]湘潭大学化工学院,湘潭411105

出　　处：《无机化学学报》2014年第7期1542-1548,共7页Chinese Journal of Inorganic Chemistry

基　　金：湖南省自科基金重点项目(No.12JJ2008);湖南省高校创新平台开放基金项目(No.12K048);2012年湖南省大学生创新性实验计划资助项目

摘　　要：以Mg-Al-NO3水滑石(LDHs)为载体,将5-氟尿嘧啶(5-FU)通过离子交换法插入其层间,得5-FU/LDHs缓释材料。并对水滑石表面进行弱酸预处理改性,利用XRD、FTIR、TG-DSC、SEM和零电荷点(pHPZC)等表征手段,考察酸预处理对水滑石表面化学性质及微观结构的影响。结果表明,5-FU/LDHs的层间距从0.858 nm扩大到1.064 nm,层间5-FU2阴离子与主体层板通过氢键与静电作用,以呈一定角度单层交替排列于层间。酸预处理的水滑石粒径变小,层板正电荷密度增大。5-FU的释放机理是物理扩散、离子交换和药物溶解等协同作用,酸预处理可提高水滑石的缓释性能和稳定性。The drug delivery materials （5-FU/LDHs） were obtained by intercalation of 5-Fluorouracil （5-FU） into the sheets of Mg-Al-NO3 hydrotaleites （LDHs） by ion-exchange method. The surface of the LDHs was modified with weak acid pretreatment. The influence of the acid-pretreatment on the surface chemical characteristics and microstructure of the LDHs was determined using X-ray diffractometry （XRD）, Fourier transform-infrared spectrometer （FTIR）, Thermo gravimetric and Differential scanning calorimeter （TG-DSC）, Scanning electron microscopy （SEM） and point of zero charge （pHpzc）. The results showed that the interlayer spaces of the 5-FU/ LDHs were expanded from 0.858 to 1.064 nm. 5-FU2 anions were intercalated into the brucite sheets of the LDHs as a monolayer arranged alternately with a constant angle through hydrogen bonding and electrostatic attraction. Average particle size became smaller and permanent charge density of the sheets increased after the aeid-pretreatment of the carrier. The release mechanism of the 5-FU was discussed. The in vitro releasing behavior of the 5-FU/LDHs materials was involved in physical diffusion, ions exchange and drug dissolution and so on. The release performances and thermostability could be improved after acid pretreatment.

关 键 词：水滑石 5-氟尿嘧啶 插层 酸预处理 载体 

分 类 号：O614.22[理学—无机化学] O614.31[理学—化学]