南昌社区中老年女性产次等因素与代谢综合征的相关性研究  

Relationship of parity and other factors with metabolic syndrome in middle-aged and elderly women in Nanchang community

作　　者：徐芳华[1] 霍亚南[1] 吴明斌[1] 刘精东[1] 章玉玲[1] 

机构地区：[1]江西省人民医院内分泌科,南昌330006

出　　处：《中华内分泌代谢杂志》2014年第6期460-463,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的 了解南昌社区中老年女性产次等生育相关因素与代谢综合征的相关性.方法 对南昌社区40岁及以上女性常住居民进行问卷调查.检测身高、体重、血压、血糖、血脂.获得有效人数5 894名.按照2004年中华医学会糖尿病学分会代谢综合征标准诊断.分析年龄、受教育程度、职业、婚姻状况、产次、巨大儿生育史、哺乳时间、月经初潮年龄、绝经年龄与代谢综合征的关系.首先行单因素logistic分析,有统计学意义者（P＜0.05）进一步行二分类logistic回归分析,计算OR值及其95％置信区间（CI）.结果 单因素分析显示,年龄、文化程度、职业、产次、哺乳时间、绝经年龄是代谢综合征的影响因素（均P＜0.05）;婚姻状况、流产次数、巨大儿生育史、月经初潮年龄与代谢综合征不相关（均P＞0.05）.二元logistic回归分析显示,相对于年龄40 ～ 49岁组而言,50～59岁、60 ～ 69岁、≥70岁组的患病风险逐渐增加,分别为OR=1.51（95％ CI0.98 ～2.32）、OR=2.10（95％ CI 1.34 ～ 3.30）、OR=2.63（95％CI1.61～4.31）;非体力劳动者相对于体力劳动者患病风险增加,OR=1.33（95％ CI 1.04～1.70）.相对于产次1次组而言,2产次、3产次、4产次的患病风险逐渐增加,分别为OR=1.46（95％ CI 1.14～1.88）、OR=1.78（95％ CI 1.30 ～2.43）、OR=1.84 （95％ CI 1.24 ～ 2.72）;随着绝经年龄增加,患代谢综合征的患病风险降低,绝经年龄每推迟1岁,代谢综合征患病风险降低6％,OR=0.94（95％ CI0.90～0.99）.文化程度和哺乳时间对代谢综合征的相关性无显著意义（P＞0.05）.结论 多产次、早绝经、少体力劳动和增龄可能会增加女性代谢综合征的发生风险.Objective To investigate the relationship of parity and other reproduction-associated factors with metabolic syndrome（MS） in middle-aged and elderly women in Nanchang community.Methods Female permanent residents over 40 years old were sampled for a routine examination and a questionnaire survey covering basic information,5 894 subjects were enrolled and identified as effective cases.MS was diagnosed according to the standard of China Diabetes Society in 2004.Factors including age,education,profession,marital status,parity,child-bearing history of macrosomia,breastfeeding,menarche age,and menopausal age were analyzed in order to find their relationship with MS.The univariate logistic analysis was followed by binary logistic regression analysis if P＜0.05,and OR value and confidence interval were calculated.Results Univariate logistic regression analysis showed that age,education,profession,parity,breastfeeding,and menopausal age were influencing factors of MS （all P ＜ 0.05）.There was no correlation to marital status,miscarriage history,child-bearing history of macrosomia,menarche age with MS（all P＞0.05）.Binary Logistic regression analysis showed that the risk of MS increased with age：OR =1.51 （95 ％ CI 0.98-2.32） during 50-59 years,OR =2.10 （95 ％ CI 1.34-3.30） during 60-69 years,and OR =2.63 （95 ％ CI 1.61-4.31） in cases aged over 70 years,as compared to the group aged 40-49 years.The risk in non-manual workers increased about 34 percent OR =1.33 （95 ％ CI 1.04-1.70）,compared with manual workers.The risk of MS increased with parity,being OR =1.46 （95％ CI 1.14-1.88）,OR =1.78 （95％ CI 1.30-2.43）,and OR =1.84 （95％ CI 1.24-2.72）,with 2,3,and 4 child-bearings respectively as compared to cases with only one childbearing.The risk of MS was reduced with advancing menopausal age being about 6 percent reduction with each increased year of menopausal age（OR =0.94,95％ CI 0.90-0.99）.There was no difference between education,breastfeeding and MS（P＞005）.Conclus

关 键 词：代谢综合征 中老年女性 产次 

分 类 号：R589[医药卫生—内分泌]