曲普瑞林兴奋试验对青春发育延迟的诊断意义：128例报告  

Clinical value of triptorelin stimulation test in differential diagnosis of disorder due to delayed puberty： 128 cases report

作　　者：丁艳霞[1] 李志臻[1] 王庆祝[2] 冉慧[1] 谢子一 秦贵军[1] 

机构地区：[1]郑州大学第一附属医院内分泌科,450052 [2]郑州大学第一附属医院核医学科,450052

出　　处：《中华内分泌代谢杂志》2014年第6期482-485,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的 评估促性腺激素释放激素（GnRH）类似物（曲普瑞林）兴奋试验对青春发育延迟的诊断意义.方法 对128例青春发育延迟患者行曲普瑞林兴奋试验,其中特发性低促性腺激素性性腺功能减退症（IHH）77例,体质性青春发育延迟（CDP）51例,在试验前15 min和注射曲普瑞林后0、30、60和120min采血测定LH和FSH.对其中3例IHH患者行GnRH延长试验.结果 LH峰值、FSH峰值、LH增加值诊断价值较高.以LH峰值8.2 IU/L作为鉴别IHH和CDP的切割值,敏感性为87％,特异性为80.4％、结论 以曲普瑞林兴奋试验LH峰值8.2 IU/L作为鉴别青少年IHH和CDP的切点具有较高的敏感性和特异性.GnRH延长试验可明确下丘脑或垂体性低促性腺激素性性腺功能减退症.Objective To evaluate the diagnostic value of triptorelin stimulation test in disorders due to delayed puberty.Methods Triptorelin stimulation test was carried out in 128 teenagers with delayed puberty,due to idiopathic hypogonadotropic hypogonadism（IHH） in 77 cases and constitutional delayed puberty（CDP） in 51.Blood samples were obtained 15 min before and 0,30,60,and 120 min after tripotorelin administration,and the levels of LH and FSH were determined.An extended GnRH stimulation test was carried out in 3 patients with IHH.Results Peak LH,peak FSH,and LH increment were parameters with high diagnostic value.A cut-off point at 8.2 IU/L of peak LH showed a sensitivity of 87％ and a specificity of 80.4％ in the differential diagnosis of IHH and CDP.Conclusion Peak LH cut-off point at 8.2 IU/L of triptorelin stimulation test seems to be sufficient to confirm diagnosis of IHH and CDP.An extended GnRH stimulation test may distinguish hypothalamic from the pituitary hypogonadotropic hypogonadism.

关 键 词：特发性低促性腺激素性性腺功能减退症 体质性青春发育延迟 曲普瑞林兴奋试验 LH 

分 类 号：R588[医药卫生—内分泌]