无锡地区50岁以上居民肥胖及相关指标与胰岛素抵抗的关系  

Relationship between obesity and related indicators with insulin resistance among the residents over 50-year-old in Wuxi area

作　　者：王冠怡[1] 许岚[1] 蒋艳敏[1] 凌冰玉[1] 姚勇[2] 朱晓巍[1] 

机构地区：[1]南京医科大学附属无锡人民医院内分泌科,无锡214023 [2]南京医科大学附属无锡人民医院眼科,无锡214023

出　　处：《中华内分泌代谢杂志》2014年第6期495-498,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：江苏省卫生厅医学重点学科开放课题（WKF0811）

摘　　要：分析无锡地区50岁以上居民肥胖及相关衡量指标与胰岛素抵抗关系的特点以5 316名无锡地区50岁及以上的常住居民为研究对象,记录性别、年龄及一般情况,测量身高、体重、腰围及臀围等,并检测相关代谢指标.该人群肥胖患病率为11.95％,其中中心性肥胖率占57.24％,男性均小于女性（P＜0.05）;随着体重指数及腰围的增加,胰岛素抵抗发生率逐步增加（P＜0.05）;同时随着稳态模型评估的胰岛素抵抗指数（HOMA-IR）增加,肥胖率及中心性肥胖率（P＜0.05）;体重指数、腰围及腰臀比对胰岛素抵抗均有一定的预测价值,并且男性腰围切点为87.5 cm,女性腰围切点为84 cm;相同体重指数水平人群中,中心性肥胖组的代谢指标大多高于对照组,且在体重指数正常组中代谢指标的升高有统计学意义（P＜0.05）;体重正常代谢性肥胖组的代谢指标大多高于代谢正常性肥胖组,其中以空腹血糖、胰岛素、HOMA-IR差异有统计学意义 无锡市50岁以上人群中肥胖（尤其是中心性肥胖）与胰岛素抵抗密切相关,同时腰围能够及时有效地预测胰岛素抵抗,预防代谢综合征和心血管疾病的发生.To analyze the relationship between obesity with related measurable indicators and insulin resistance among the residents over 50-year-old in Wuxi area.The questionnaire survey,physical examination,and relevant biochemical measurements as well as gender,age,height,body w eight,waist circumference,and hip circumference were obtained.The prevalence of obesity was 11.95％ of which 57.24％ were with central obesity,and the prevalence in male was higher than that in female（P＜0.05）.With inereasing body mass index （BMI） and waist circumference（WC）,the prevalence of insulin resistance increased gradually （P ＜ 0.05）.Meanwhile,With the increasing HOMA-IR,the prevalence of obesity and central obesity also gradually increased （P＜0.05）.BMI,WC,and waist-to-hip ratio can effectively predict insulin resistance.The cut-off point of waist circumference was 87.5 cm for male,and 84 cm for female.At the same level of body mass index,metabolic measurements in central obesity group were higher than those of non-central obesity group with the same body mass index,especially in normal weight group.The related metabolic measurements of metabolic obesity but normal weight group were mostly higher than metabolically healthy but obese group,and there were statistically significant differences in fasting blood glucose,fasting insulin,HOMA-IR and HOMA-β.Obesity,especially central obesity,is closely related to insulin resistance among residents over 50-year-old in Wuxi area.Meanwhile,waist circumference may effectively predict insulin resistance and may serve as a parameter in the occurrence of metabolic syndrome and cardiovascular diseases.

关 键 词：肥胖症 体重指数 腰围 胰岛素抵抗 

分 类 号：R589.2[医药卫生—内分泌]