脑室-腹腔分流术治疗隐球菌性脑膜炎  

The study on the role of ventriculoperitoneal shunts in the treatment of cryptococcal meningitis

作　　者：欧阳宛炯[1] 陈雅芳[1] 林友榆 蔡若蔚[1] 黄银辉[2] 

机构地区：[1]福建医科大学附属第二医院神经内科,泉州362000 [2]福建省晋江市医院神经内科

出　　处：《中国神经精神疾病杂志》2014年第5期288-292,共5页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的探讨脑室-腹腔分流术在新型隐球菌性脑膜炎的治疗效果。方法对我院收治的54例型隐球菌性脑膜炎患者的临床资料进行回顾性分析。根据有无行脑室-腹腔分流术,将研究对象分为脑室-腹腔分流术组,无脑室-腹腔分流术组。结果 23例行脑室-腹腔分流术治疗的新型隐球菌性脑膜炎患者治愈率78.26%,平均住院天数(106.00±11.97)d,其两性霉素B平均应用天数(90.17±10.95)d。对照组31例,治愈率48.39%,其治愈者平均住院天数(153.03±28.35)d,两性霉素B平均应用天数(127.70±28.93)d。两组在治愈率、恶化率、治愈者平均住院天数、治愈者两性霉素B平均应用天数等临床疗效之间有显著性差异(P=0.026、0.032、0.000、0.000)。结论脑室-腹腔分流术治疗新型隐球菌性脑膜炎可提高治愈率,缩短疗程。Objective To study the role of ventriculoperitoneal shunts in the treatment of cryptococcal meningitis. Methods The clinic data of patients with cryptocoecal meningitis were retrospectively studied. Results In the ventriculoperitoneal shunts group , 78.26% of patients fully recovered and their average hospital stay and average treatment period with amphoteric in B were 106.00±11.97 and 90.17±10.95 days, respectively. In the no-ventriculoperitoneal shunts group, 48.39% of patients fully recovered and their average hospital stay and average treatment period with amphoteric in B were 153.03±28.35 and 127.70±28.93 days, respectively. The clinical efficacy in the cure rate and deterioration rate and average hospital stay and average treatment period with amphoteric in B were better in ventriculoperitoneal shunts group than in noventriculoperitoneal shunts group （P=0.026, 0.032,0.000, 0.000）. Conclusions ventrieuloperitoneal shunts is a valuable approach in the treatment of cryptococcal meningitis in that it can improve the cure rate and shorten the period of treatment.

关 键 词：脑室-腹腔分流术 新型隐球菌性脑膜炎 疗效 

分 类 号：R651.1[医药卫生—外科学]