代谢组学方法在妊娠期糖尿病研究中的应用  

The Application of Metabolomics for Gestational Diabetes Mellitus

作　　者：周玲[1] 沈桂平[1] 许晶晶[1] 邓伶莉[1] 董继扬[1] 黄秀敏[2] 

机构地区：[1]厦门大学电子科学系,福建省厦门市361005 [2]厦门大学附属中山医院妇产科

出　　处：《国际妇产科学杂志》2014年第3期213-217,共5页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金(81201143;81371639);中央高校基本科研业务费(2013121007)

摘　　要：妊娠期糖尿病(GDM)易造成子痫前期、羊水过多、巨大儿等多种并发症。目前在妊娠中晚期检测血糖筛查GDM,确诊患者接受治疗的时间短,母婴健康存在严重隐患。代谢组学(metabolomics)是一种定量考察生命系统受内外界刺激或基因修饰后的代谢应答规律的学科。将代谢组学的方法应用于GDM研究,有望实现GDM的早期诊断,理解GDM的致病机制,对GDM的防治和母婴预后都有重要的意义。综述代谢组学方法在GDM及相关疾病研究中的应用。Gestational diabetes mellitus （GDM） easily lead to some complications,such as preeclampsia, polyhydramnios,macrosomia,and so on. The traditional diagnostic protocols for GDM mainly rely on detecting elevated glucose levels in blood,often late in the second trimester. Therefore the treatment time for the patients is not enough and the serious risk to maternal and child health raise. Metabolomics is an approach that investigates the metabolic responses of living systems to internal or external stimuli or genetic modification. The application of metabolomics to GDM research will help to interpret the pathogenesis of GDM. In addition,it can also provide the theoretical and experimental support for prevention and treatment of GDM as well as the prognosis of mothers and their infants. The characteristics of the common detection methods and the metabolomics studies of GDM were analyzed and compared in detail in this paper ,and the metabolomic studies in GDM was further reviewed.

关 键 词：糖尿病 妊娠 羊水 血浆 尿 代谢组学 

分 类 号：R714.256[医药卫生—妇产科学]