胎粪吸入综合征合并肺动脉高压的临床分析  

CLINICAL ANALYSIS OF MECONIUM ASPIRATION SYNDROME COMPLICATED PULMONARY HYPERTENSION

作　　者：王沛[1] 傅万海[1] 孟琼[1] 赵雪婷[1] 

机构地区：[1]广东省第二人民医院,广东广州510317

出　　处：《现代医院》2014年第6期11-14,共4页Modern Hospitals

基　　金：广东省科技计划项目(编号:2012B031800478)

摘　　要：目的观察常频机械通气并硫酸镁治疗新生儿胎粪吸入综合征（MAS）合并持续肺动脉高压（PPHN）的疗效。方法2008年1月-2014年2月我院NICU收治胎粪吸入综合征患儿107例，对其中8例并发持续肺动脉高压的患儿使用常频机械通气并硫酸镁治疗，对患儿治疗情况进行回顾性分析，并于治疗前及治疗詹6、12、24h监测动脉血气；采用SPSS16．0软件分析，数据以（x^-±s）表示，对组内数据进行配对t检验，p〈0．05为差异有统计学意义。结果1例死亡，余7例治疗后血pH值、PCO2、SaO2均较治疗前明显改善，差异有统计学意义（P〈0．05）；治疗后6h患儿血PO2与治疗前相比，差异无统计学意义（p〉0．05），治疗后12、24h均较治疗前明显升高，差异有统计学意义（P〈0．05）。结论常频机械通气并硫酸镁治疗MAS合并PPHN有良好疗效，且使用方便。Objective To observe the conventional mechanical ventilation and magnesium sulfate in the treatmem of meconinm aspiration syndrome （MAS） complicated with persistent pulmonary hypertension of newborn （ PPHN ）. Methods From January 2008 to February 2014,NICU of our hospital admitted 107 cases of MAS,among them there were 8 cases complicated with PPHN ,which we used conventional mechanical ventilation and magnesium sulfate for the treatment. And then these cases were analyzed retrospectively ,before treatment and after treatment of 6,12,24 h monitor arterial blood gas. SPSS 16. 0 analysis software,data expressed as a （x^- ＋ s） ,paired T test data within the groups,p 〈 0. 05 differences were statistically significant. Results After treatment,one children death, the other seven children＇s blood pH value 、PCO2 , SaO2 were obviously improved,the differences was statistically significant （p 〈 0. 05 ）. PO2 after 6h treatment compared with before treatment, there was no statistically significant （p 〉0. 05）. After 12 h and 24 h treatment,There was no statistically significant （p 〉0. 05） in PO2 after 6 h treatment compared with before treatment. Conclusion Therapeutic effect of conventional mechanical ventilation and magnesium sulfate for MAS complicated with PPHN is good and convenient.

关 键 词：常频机械通气 硫酸镁 胎粪吸入综合征 持续肺动脉高压 

分 类 号：R722.12[医药卫生—儿科]