刺激蓝斑及电针对大鼠脊髓背角神经元伤害性反应的影响  

EFFECT OF LOCUS COERULEUS STLMULATION AND ELECTROACUPUNCTURE ON NOCICEPTIVE RESPONSE OF SPINAL DORSAL HORN NEURONS IN RATS

作　　者：俞光弟[1] 崔存德[2] 张惠琴[1] 殷伟平[1] 印其章[1] 

机构地区：[1]苏州医学院神经生物学研究室 [2]山东省滨州医学院

出　　处：《生理学报》1990年第1期76-81,共6页Acta Physiologica Sinica

基　　金：核工业部和江苏省卫生厅资助

摘　　要：以往的工作表明,蓝斑(LC)-去甲肾上腺素能神经元系统在痛觉调制和针刺镇痛中起着重要作用,本文用电生理学方法研究刺激 LC 和电针对大鼠脊髓背角神经元伤害性反应的影响,其主要结果如下:1.刺激 LC 或电针有明显抑制脊髓背角神经元伤害性反应的作用。2.损毁中缝大核和腹腔注射纳洛酮并不明显影响刺激 LC 的抑制效应。3.α_2受体激动剂氯压啶能加强刺激 LC 或电针的抑制效应,而α受体阻断剂酚妥拉明在一定程度上能削弱这种抑制效应。这些实验结果提示,刺激 LC 和电针可激活 LC 神经元,通过其下行纤维,在脊髓水平释放 NE,通过α_2受体,阻断伤害性信息的传递。Previous studies have demonstrated that locus coeruleus(LC)-noradrenergicneuronal system plays an important role in pain modulation and electroacu-puncture(EA)analgesia.In the present experiment,the effect of LC stimulationand EA on nociceptive response of spinal dorsal horn neurons was investigated.The main results were:1)LC stimulation and electroacupuncture produced a sig-nificant inhibitory effect on nociceptive response of dorsal horn neurons;2)Theinhibitory effect of LC stimulation was not affected by the lesion of nucleus raphemagnus or by the injection of naloxone;3)These inhibitory effects of LC stimulationand electroacupuncture could be enhanced by α_2-agonist clonidine,and decreasedslightly by α-antagonist phentolamine.These results suggest that the inhibitory effect of LC stimulation and electro-acupuncture on the nociceptive response of dorsal horn neurons might be mediatedby α_2-receptors.

关 键 词：蓝斑 中缝大核 脊髓背角神经元 伤害性反应 电针 痛觉调制 

分 类 号：Q426[生物学—神经生物学] R246.2[生物学—生理学]