支气管哮喘患者血清25-羟维生素 D水平与肺功能的相关性  

The relationship between vitamin D levels and lung function of patients with bronchial asthma

作　　者：张学青[1] 

机构地区：[1]山东省济宁市第一人民医院呼吸内科,272000

出　　处：《中国综合临床》2014年第7期709-711,共3页Clinical Medicine of China

摘　　要：目的：探讨支气管哮喘患者血清25-羟维生素 D[25（OH）D3]水平与肺功能的相关性。方法选取我院呼吸内科2013年1-10月重度、中度、轻度哮喘患者各13例，另选择我院同期健康体检者15名为对照组，分别进行血清25（OH）D3和肺功能指标的检测，计算第1秒用力呼气容积占预计值百分比（FEV1％ pred）。结果轻度组、中度组和重度组患者 FEV1％ pred 分别为（86.62±10.80）％、（67.23±11.30）％和（31.26±12.80）％，两两比较差异均有统计学意义（P 均＜0.01）；对照组与轻度、中度和重度支气管哮喘组25（OH）D3分别为（17.28±7.12）、（14.33±6.82）、（10.28±5.51）、（5.68±3.26）μg/ L，两两比较差异均有统计学意义（P ＜0.01或0.05）。支气管哮喘患者血清25（OH）D3水平（y）与肺功能（x）呈直线正相关，直线回归方程：y =-0.0115＋0.167x。结论维生素 D 缺乏与支气管哮喘的发病及病情程度相关，补充维生素 D 也应作为支气管哮喘患者的一种治疗手段。Objective To investigate the relationship between serum 25- hydroxyvitamin D（25（OH） D3）level and lung function of bronchial asthma patients. Methods Thirty-nine bronchial asthma patients with severe,moderate,mild stage（each for 13 cases）in respiratory department of the First People＆#39;s Hospital of Jining from Jan. to Oct. 2013 were selected as our subjects. Fifth healthy people were selected as control group. Serum 25（OH）D3 and pulmonary function indexes were detected,and the percentage of forced expiratory volume in one second（FEV）in predicted value（FEV1% pred）was calculated. Results The FEV1% pred of patients with mild,moderate and severe stage bronchial asthma were（86. 62 ± 10. 80）% ,（67. 23 ± 11. 30）% and（31. 26 ± 12. 80）% pespectively,and there were significant between groups（P 〈 0. 01）. The level of 25（OH）D3 in patients with mild,moderate and severe bronchial asthma were（14. 33 ± 6. 82）,（10. 28 ± 5. 51）,（5. 68 ± 3. 26）μg/ L respectively,lower than that in control group（（17. 28 ± 7. 12）μg/ L）,and the differences were statistically significant（P 〈 0. 01 or 0. 05）. There was a positive correlation between serum 25（OH）D3 and pulmonary function,and the linear regression equation was：y = - 0. 0115 ＋ 0. 167x. Conclusion The deficiency of Vitamin D relate to the occrrence and degreed of bronchial asthmaisease,and suppliment of vitamin D should also be used as a therapy in patients with bronchial asthma.

关 键 词：支气管哮喘 维生素D 肺功能 

分 类 号：R562.25[医药卫生—呼吸系统]