模拟移动床分离盐酸度洛西汀的研究  

Study on Separation of Duloxetine Hydrochloride on Simulated Moving Bed

作　　者：来梦龙[1] 

机构地区：[1]温州大学化学与材料工程学院,浙江温州325035

出　　处：《辽宁化工》2014年第6期793-795,800,共4页Liaoning Chemical Industry

基　　金：浙江省大学生科技创新活动计划(新苗人才计划);项目号:2011R424021

摘　　要：通过HPLC单柱实验,确定了盐酸度洛西汀的拆分条件。采用平衡扩散模型对盐酸度洛西汀在8柱四区模拟移动床上的线性分离过程进行了模拟,主要考察了切换时间对分离效果的影响。在适宜的操作条件下,达到了较好的分离效果。两种对映体的纯度分别达到99.67%和99.62%,回收率分别达到了96.30%和97.14%。本研究对盐酸度洛西汀的生产应用具有一定的指导意义和参考价值。The separation conditions of duloxetine hydrochloride were confirmed through single column experiments on HPLC. Linear separation of duloxetine hydrochloride on a 4-zone simulated moving bed consisting of 8 chromatography columns was simulated by using Equilibrium Dispersive Model. The effect of switching time on the separation efficiency was investigated. The results show that better separation effect can be obtained under appropriate conditions,two kinds of enantiomers＇ purities are up to 99.67% and 99.62%, the yields are 96.30% and 97.14% ,respectively. This study can provide the guidance and reference to the production of duloxetine hydrochloride.

关 键 词：HPLC 盐酸度洛西汀 模拟移动床 

分 类 号：TQ028.9[化学工程]