军事应激对血清和胃黏膜肿瘤坏死因子-α水平的影响  

Influence of military stress on levels of tumor necrosis factor-α in serum and gastric mucosa

作　　者：高娟[1] 徐维田[1] 熊毅敏[1] 王一鸣[1] 王艳[1] 郑国荣[1] 

机构地区：[1]广州军区武汉总医院消化内科,430070

出　　处：《武警医学》2014年第6期557-559,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨军事演习前后部队官兵血清和胃黏膜肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)的水平及其意义。方法分别采用酶联免疫和免疫组化的方法检测某部60名官兵军事演习(简称军演)前后血清和胃黏膜TNF-α的水平。结果军演前官兵外周血血清中TNF-α的含量为(38.05±15.49)pg/ml,军演后为(92.93±30.98)pg/ml,较军演前明显上升(P<0.01)。军演前后TNF-α均主要表达于胃黏膜固有层腺上皮细胞和间质单个核细胞中,军演后该分子的表达明显强于军演前(P<0.01)。结论 TNF-α可能中介了军事应激所致的胃黏膜病变。在军事应激早期检测该细胞因子的含量,有助于评估发生胃黏膜病变的可能性及严重程度。Objective To investigate the levels of TNF-α in serum and gastric mucosa before and after military stress and their significances. Methods The level of serum TNF-α in 60 soldiers was studied by enzyme-linked immunosorbent assay. The expression of TNF-α in gastric mucosa from the 60 soldiers was detected by immunochemical staining. Results The level of TNF-α in serum in the soldiers was （92.93 ± 30.98） pg/ml after military maneuver, and was significantly higher than that of （38.05 ± 15.49 ） pg/ml before military maneuver （P 〈0.01 ）. TNF-α was found to be expressed in the lamina propria epithelioglandular ceils and in the mesen- chymal mononuclear cells in gastric mucosa of the soldiers before and after military maneuver. The expression of TNF-α was also significantly stronger after military maneuver compared with that before military maneuver （P 〈 0.01 ）. Conclusions TNF-α might be involved in the development of the pathological changes of gastric mucosa caused by military stress in the troops. It will be helpful to examine the level of TNF-α in the early stage of military stress for evaluating the possibility of the occurrence of gastric mucosa lesion and its severity.

关 键 词：肿瘤坏死因子-Α 军事应激 血清 胃黏膜病变 

分 类 号：R823[医药卫生—临床医学]