北京市西城区健康人群麻疹抗体水平调查  

Investigation on the measles antibody level in healthy population in Xicheng district, Beijing

作　　者：史淑芬[1] 王庆[1] 王兆华[1] 

机构地区：[1]北京市西城区疾病预防控制中心,北京100120

出　　处：《国际病毒学杂志》2014年第3期139-141,共3页International Journal of Virology

摘　　要：目的调查北京市西城区健康人群麻疹抗体水平，为调整现有免疫策略、有效控制麻疹疫情，实现消除麻疹目标提供依据。方法按容量比例概率抽样法（probability proportion to size，pps）抽样的方法，2012年在北京市西城区随机选择10个居委会，每个居委会随机抽取在京连续居住6个月以上的人员22名作为调查对象，共220名。采用面对面问卷调查收集调查对象的人口学特征、含麻疹成分疫苗免疫史，并采集静脉血5ml。使用ELISA方法检测研究对象麻疹IgG抗体水平。结果调查对象麻疹抗体阳性率为85．91％，抗体水平中位数为976IU·l-1。不同年龄组人群中，麻疹抗体阳性率和抗体水平差异均具有统计学意义（χ2=42．39，P〈0．01；H=38．84，P〈0．01），其中8月龄以下儿童抗体阳性率和抗体水平最低，分别为21．43％、120IU·l-1；1～4岁、5～9岁儿童及40岁以上成人较高，阳性率均达95．45％，抗体水平中位数分别为3059IU·l-1、2099Iu·l-1、2308IU·l-1；其余年龄组人群抗体阳性率在72．73％～95．45％之间，抗体水平在512～1679IU·l-1之间。未接种过麻疹疫苗的人群麻疹抗体阳性率和抗体水平明显低于接种过疫苗和接种情况不详的人群（χ2=28．73，P〈0．01；H=1．56，P〈0．01），差异有统计学意义。结论北京市西城区常住人口中，1～9岁儿童麻疹抗体水平较高，发生大范围麻疹暴发和流行的风险较小，〈8月龄婴儿和15～40岁人群麻疹抗体水平有待进一步提高。Objective To identify the level of measles antibody in healthy population , and provide scientific immunization strategy for the elimination of measles. Methods The subjects who had been living for over 6 months in Beijing were recruited for this study. Pps sample method was used to select 220 objects from 10 age groups. Demographic characteristics, vaccine immunization were investigated by questionnaire. The measles IgG antibody was measured by EL[SA assay. Results Positive rate against measles antibody was 85.91%. Median of antibody was 976 IU·l-1. Positive rate and median of measles antibody were signif- icantly different between population from different age groups （χ2 = 42. 39,P 〈 0. 01 ; H = 38.84, P 〈 0. 01 ）. Antibody positive rate and median were lowest in the 〈 8 month age group, which were separately 21.43% , 120 IU·l-1 ;and highest in the 1-4, 5-9 and 〉 40 year age group,their positive rate all reach 95.45% and median were separately 3059 IU·l-1 , 2099 IU ·l-1, 2308 IU ·l-1. The range of antibody positive rate and median in other year group were 72. 73% -95.45% and 512 - 1679 IU·l-1, respectively. Antibody positive rate and median in population without vaccination history were lower than those population with vaccination history and people whose history unknown. The difference showed statistical significance （χ2= 28.73,P 〈 0. 01 ; H = 1.56, P 〈 0. 01 ）. Conclusions Among the persistent population in Beijing, measles antibody level among the children ag（ 1-9 years old ） was high enough to prevent outbreak and epidemic of measles. However, we should try our best to strengthen the measles antibody level among the babies younger than 8 month and population aging between 15 and 40 years old.

关 键 词：麻疹 抗体 疫苗 免疫 

分 类 号：R511.1[医药卫生—内科学]