清金化痰汤治疗慢性阻塞性肺疾病急性加重期临床观察  

Clinical Observation on Qingjinhuatan Decoction Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：陈旭波[1] 徐晓雯[1] 韩志青[1] 梁兴伦[2] 赵莹[3] 王梅[3] 

机构地区：[1]上海市杨浦区中心医院呼吸内科,上海200433 [2]上海市杨浦区中心医院老干部科,上海200433 [3]上海市杨浦区五角场镇社区卫生服务中心,上海200433

出　　处：《世界中医药》2014年第6期743-746,共4页World Chinese Medicine

基　　金：国家自然科学基金项目(编号:81173312)

摘　　要：目的:观察清金化痰汤治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法:将临床收集的120例慢性阻塞性肺疾病急性加重期、中医辨证属痰热郁肺型患者,随机分为治疗组和对照组各60例。对照组给予解痉、化痰、抗炎等西医常规治疗,治疗组在西医常规治疗的基础上,加服中药汤剂清金化痰汤,1剂/d,2组患者疗程均为10 d。观察2组在治疗前后临床症状、体征、肺功能、血液流变学等指标的变化。结果:2组患者疗效,治疗组显效率与总有效率(80.00%,96.67%)和对照组(53.33%,93.33%)比较,差异有统计学意义(P=0.042<0.05),说明治疗组疗效优于对照组。清金化痰汤加减改善中医症状积分、血液流变学方面优于对照组,差异有统计学意义(P<0.05)。尤其在咳嗽、痰量、哮鸣等方面改善症状优于对照组(P<0.01)。2组患者改善肺功能方面无统计学意义(P>0.05)。结论:清金化痰汤治疗慢性阻塞性肺疾病急性加重期可有效改善临床症状,提高生存质量,疗效确切,值得推广。Objective：To observe the clinical curative effect of Qingjinhuatan decoction in the treatment of chronic obstructive pulmona-ry disease in acute exacerbation period.Methods：One hundred and twenty patients with chronic obstructive pulmonary disease with a-cute exacerbation,whose TCM syndrome were phlegm heat obstructing lung type were randomly divided into treatment group （n=60 ） and control group （n=60）.Patients in the control group were given antispasmodic,phlegm,anti-inflammatory and other routine western medicine therapies,and patients in the treatment group received Qingjinhuatan decoction once a day except from the conventional thera-pies of Western medicine.Patients in both groups were treated for 10 days.The changes of clinical symptoms,signs,pulmonary function, blood rheology before and after treatment were observed.Results：As for the efficacy,the remarkable effective rate and the total effective rate of the treatment group were 80.00%%and 96.67%,and those of the control group were 96.67%and 93.33%.There was signifi-cant difference between the two groups （P=0.042 0.05）.Conclusion：Qingjinhuatan de-coction can effectively improve the clinical symptoms of patients with acute exacerbation of chronic obstructive pulmonary disease,im-prove life quality with satisfactory curative effect,and it is worth generalizing.

关 键 词：慢性阻塞性肺疾病 清金化痰汤 临床观察 

分 类 号：R256.14[医药卫生—中医内科学] R243[医药卫生—中医学]