磷酸奥司他韦治疗527例甲型H1N1流感的临床疗效和安全性回顾性研究  

Retrispective Study of Cinical Efficacy and Safety of Oseltamivir in Treatment of 527 Cases of Pandemic(H1N1)

作　　者：战寒秋[1] 王丽君[1] 孙娜[1] 刘慧[1] 李小青[1] 白淑梅 

机构地区：[1]首都医科大学附属北京地坛医院,100015 [2]新疆五家渠农六师103团医院,831503

出　　处：《首都医药》2014年第12期52-54,共3页Capital Medicine

摘　　要：目的研究磷酸奥司他韦治疗甲型H1N1流感的临床疗效及其安全性。方法采用回顾性分析方法,对我院527例使用磷酸奥司他韦的住院患者进行综合分析。结果 527例甲型H1N1流感患者中,普通型376例,重症76例,危重症75例,与发病48h后比较,48h内使用奥司他韦治疗的普通型及重症患者发热持续时间、临床症状持续时间和病毒核酸阳性持续时间明显减少,危重症患者的发热持续时间、病毒核酸阳性持续时间都明显减少,而临床症状缓解时间两组无明显差异。不同治疗时间对患者的住院时间无明显影响。普通型、重症患者均无死亡病例,危重症患者48h内与48h后治疗的死亡率无显著性差异。527例患者中不良反应20例,主要为消化系统症状。结论磷酸奥司他韦治疗甲型H1N1流感安全有效,发病48h内使用,能有效减轻病情,缩短病程。Objective To Study the cinical efficacy and safety of oseltamivir in the treatment of Pandemic（H1N1）.Methods The clinical data of 527 patients who were admitted into Beijing DiTan Hospital from 2009 to 2013 were analyzed retrospective.Results The 527 cases were dicided into 3 groups according to the severity of the clinical symptoms：common type,severe type and extremely severe type.Compared with patients therapied after 48 hours,duration of clinical symptoms,duration of fever and duration of viral nucleic acid positive were significant decrease in common type and severe type patients with oseltamivir within 48 hours.Duration of fever and duration of viral nucleic acid positive were also significant decrease in extremely severe type patients,but duration of clinical symptoms was not significant difference.Hospitalization time in the three groups were not statistically significant.There were no dead cases in common type and severe type patients.The difference of mortality rate in extremely severe type patients with oseltamivir in different time was not significant.Adverse drug reactions of 20 cases mainly occurred in digestive system.Conclusion Osehamivir was effective and safety in the treatment of Pandemic（H1N1）.Therapiy with oseltamivir in 48 hours would effectively ameliorate the symptomsand shorten the course of the disease.

关 键 词：磷酸奥司他韦 甲型H1N1流感 有效性 安全性 

分 类 号：R511.7[医药卫生—内科学]