地奥司明片治疗腰椎间盘突出症急性期疗效观察  

Efficacy Observation of Diosmin Tablets in the Treatment of Lumbar Intervertebral Disc Protrusion in Acute Stage

作　　者：曹锦[1] 胡丰根[1] 王大勇[1] 张旭晨[1] 王定[1] 

机构地区：[1]杭州师范学院医学院附属余杭医院骨科,杭州311100

出　　处：《中国药师》2014年第6期1000-1002,共3页China Pharmacist

摘　　要：目的：观察地奥司明片治疗腰椎间盘突出症急性期在临床应用疗效.方法：腰椎间盘突出症患者210例随机分为观察组（115例）和对照组（95例）.全部患者均绝对卧床休息2周,观察组同时口服地奥司明片0.9g,po,tid,10 ～20 d;对照组同时以甘露醇联合地塞米松静滴,3d后停药.比较两组患者临床疗效、疼痛程度VAS评分和药物安全性.结果：观察组总有效率86.08％,与对照组治疗效果（89.47％）相当（P＞0.05）;两组治疗后VAS评分均较治疗前显著降低（P＜0.05）,治疗后3d,观察组VAS评分高于对照组（P＜0.05）,治疗10d后,两组VAS评分比较差异无统计学意义（P＞0.05）.结论：地奥司明片治疗腰椎间盘突出症急性期有较明显的临床疗效.Objective：To observe the therapeutic efficacy of diosmin tablets in the treatment of lumbar intervertebral disc protrusion in acute stage.Methods：Totally 210 cases of patients with lumbar intervertebral disc protrusion were randomly divided into the treatment group （115 cases）and the control group （95 cases）.The treatment group stayed in bed absolutely for two weeks and received diosmin tablets orally with 2 tablets each time （0.45 g per tablet）and three times a day for 10 days （one treatment course）.The control group stayed in bed absolutely for two weeks and received rapid intravenous dripping of mannitol combined with dexamethasone for 3 days.The clinical efficacy,VAS scores and adverse drug reactions were observed and compared between the two groups.Results：The total effective rate of the treatment group was 86.08%,and that of the control group was 89.47%,suggesting the therapeutic efficacy of the two groups was similar.The score of VAS ofthe two groups were decreased significantly after the treatment （P 〈 0.05）.After 3 days treatment,the score of VAS in the treatment group was higher than in the control group（P 〈 0.05）,however,there was no statistical significance（P 〉 0.05） between the two groups after 10 days treatment.Conclusion：Diosmin tablets show obvious effect on lumbar intervertebral disc protrusion in acute stage.

关 键 词：腰椎间盘突出症 地奥司明片 疗效 

分 类 号：R681.53[医药卫生—骨科学]