白介素-11联合循证护理对血液病化疗患者口腔黏膜炎疗效的影响  

Influence of IL-11 and Evidence-based Nursing on Clinical Effects of Oral Mucositis of Blood Disease Patients Undergoing Chemotherapy

作　　者：沈世银[1] 周维华[1] 陈丽萍[1] 李霞[1] 

机构地区：[1]东南大学医学院附属江阴医院血液内科,江苏江阴214400

出　　处：《西部中医药》2014年第6期126-128,共3页Western Journal of Traditional Chinese Medicine

摘　　要：目的:探讨白介素-11(IL-11)联合治疗对循证护理血液病化疗患者口腔黏膜炎疗效的影响。方法:选择2012年1月至2013年1月50例血液病化疗期间出现口腔黏膜炎患者,随机分为观察组和对照组,均给予IL-11溶液含漱。对照组应用常规护理,观察组采用循证护理,观察2组治疗10天后治愈率、愈合时间、口腔黏膜炎反应程度、疼痛视觉模拟评分(VAS评分)。结果:观察组治愈率为80.00%,明显高于对照组的(P<0.05);观察组愈合时间为(6.72±2.43)天,显著少于对照组(P<0.05);观察组口腔黏膜反应程度明显轻于对照组(P<0.05),VAS评分显著低于对照组(P<0.05)。结论:循证护理可提高IL-11治疗血液病化疗患者口腔黏膜炎的临床疗效。Objective： To survey the influence of evidence-based nursing and interleukin-11 （IL-11） on curative effects of oral mucositis of blood disease patients undergoing chemotherapy. Methods：During the period of chemotherapy, 50 cases of blood disease patients who were suffering from oral mucositis were chosen from January, 2012 to January, 2013, and randomly separated to the observation group and the control group, they were gargled with IL-11 solution. The control group were applied to routine care and the observation group evidence-based nursing, visual analogue scale （VAS）, the degree of oral mucositis, healing time and healing rate of both groups were observed after treating for ten days. Results：Cure rate of the observation group was 80.00%, notably higher than the control group （P＆lt;0.05）; healing time of the observation group was （6.72 ＆#177;2.43）days, significantly less than the control group （P＆lt;0.05）;the degree of oral mucositis in the observation group was obviously lighter than that of the control group （P＆lt;0.05）, VAS scale of the observation group was remarkably lower than that of the control group （P＆lt;0.05）. Conclusion：Evidence-based nursing could increase clinical effects of IL-11 in treating oral mucositis of blood disease patients undergoing chemotherapy.

关 键 词：循证护理 白介素-11 血液病 化疗 口腔黏膜炎 疗效 

分 类 号：R552[医药卫生—血液循环系统疾病]