HBV/HCV重叠感染的研究进展  

Research progress in HBV /HCV co- infection

作　　者：何丽[1] 胡萍[1] 申焕君[1] 张野[1] 黄长形[1] 

机构地区：[1]第四军医大学唐都医院传染科,西安710038

出　　处：《临床肝胆病杂志》2014年第6期569-572,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(81072434);国家"十一五"科技重大专项(2008ZX10002-006)

摘　　要：HBV是一种嗜肝DNA病毒,HBV DNA和HBV特异P蛋白由核壳包裹成为核心颗粒,再由脂蛋白外膜包裹成完整的病毒颗粒。HCV是黄病毒科病毒,为单股正链RNA。HBV和HCV均由肠道外途径传播,2种病毒常可由相同途径发生感染。归纳了HBV/HCV重叠感染的发病机制、与隐匿性HBV感染和肝细胞癌以及器官移植、HBV疫苗之间的关系,同时介绍了重叠感染的治疗。指出存在于患者体内的HBV和HCV在病毒学方面相互干扰,在病变方面相互叠加。Hepatitis B virus （HBV）is a hepatotropic DNA virus;HBV DNA and special P protein are covered by capsid proteins to form core particles,which are then covered by lipoprotein to form complete virus particles.Hepatitis C virus （HCV）,which belongs to the Flavi-viridae family,is a single-stranded,positive-sense RNA.HBV and HCV are transmitted by parenteral route and may cause co-infection through the same route of transmission.The pathogenesis of HBV/HCV co-infection and its relationship with occult HBV infection,hepato-cellular carcinoma,organ transplantation,and HBV vaccine are reviewed.Meanwhile,the treatment of co -infection is presented.It is shown that HBV and HCV interfere with each other in terms of virology and pathology.

关 键 词：乙型肝炎病毒 丙型肝炎病毒 重叠感染 乙型综述 

分 类 号：R512.62[医药卫生—内科学] R512.63[医药卫生—临床医学]