Degradation potential of ofloxacin and its resulting transformation products during Fenton oxidation process  

作　　者：Yunqing Pi Jinglan Feng Mengke Song Jianhui Sun 

机构地区：[1]School of Environment,Henan Normal University [2]Henan Key Laboratory for Environmental Pollution Control [3]Key Laboratory for Yellow River and Huaihe River Water Environmental and Pollution Control,Ministry of Education

出　　处：《Chinese Science Bulletin》2014年第21期2618-2624,共7页

基　　金：supported by the Foundation and Advanced Technology Research Program of Henan Province (102300410098,0611020900,102300410193,and 122300410286);the Innovation Scientists and Technicians Troop Construction Projects of Henan Province;the Plan for Scientific Innovation Talent of Henan Province

摘　　要：The degradation of ofloxacin(OFX)in the aqueous solution by Fenton oxidation process was investigated in the present study.The optimum operating conditions for the degradation of OFX in our system was determined.More importantly,the degradation pathways on a basis of the identification of transformation products during the degradation of OFX were proposed,which revealed that the initial degradation step could be associated with the decarboxylation at the quinolone moiety.Moreover,the detachment of the F element during the Fenton oxidation process has also been detected.Since the carboxylic group within OFX has been considered as an important bridge for binding quinolones with the DNA gyrase target,the decarboxylation process would offer insights into the reduction of antibacterial potentials.The degradation of ofloxacin （OFX） in the aqueous solution by Fenton oxidation process was investigated in the present study. The optimum operating conditions for the degradation of OFX in our system was determined. More importantly, the degradation pathways on a basis of the identification of transformation products during the degradation of OFX were proposed, which revealed that the initial degradation step could be associated with the decarboxylation at the quinolone moiety. Moreover, the detachment of the F element during the Fenton oxidation process has also been detected. Since the carboxylic group within OFX has been considered as an important bridge for binding quinolones with the DNA gyrase target, the decarboxylation process would offer insights into the reduction of antibacterial potentials.

关 键 词：降解途径 氧氟沙星 转化产物 氧化过程 FENTON 最佳操作条件 喹诺酮类 反应过程 

分 类 号：TQ460.1[化学工程—制药化工]