卵巢早衰的颗粒细胞凋亡机制研究进展  

The progress in apoptotic mechanism of ovarian granulosa cells involved in premature ovarian failure

作　　者：叶娜[1] 董晓英[2] 李冬华[2] 

机构地区：[1]首都医科大学基础医学院七年制临床医学专业,北京100069 [2]首都医科大学中医药学院中医系中医基础教研室,北京100069

出　　处：《首都医科大学学报》2014年第3期379-383,共5页Journal of Capital Medical University

基　　金：国家自然科学基金面上项目(81073096);首都医科大学学生科研创新项目(xsky2013048);首都医科大学基础临床合作课题(708016);北京中医药薪火传承“3+3”工程项目(2012-SZ-C-41)~~

摘　　要：卵巢早衰发病率日益增高,已经成为严重危害女性身心健康的疾病,近年来对其病因的研究很多,目前认为,造成这种疾病的原因是多方面的,主要有基因缺陷、激素及其受体缺陷、代谢紊乱以及自身免疫失常。此外,一些人为的机械性损伤,也可以诱发卵巢早衰,但其确切机制仍未可知。众多研究显示无论是何原因引起卵巢早衰,都伴有颗粒细胞的凋亡,这也说明了颗粒细胞的凋亡与卵巢早衰有着直接的关系。因此,本文就当前关于卵巢早衰中颗粒细胞凋亡的研究进展加以综述,提出卵巢早衰的细胞凋亡机制,旨在为后续研究提供参考。Premature ovarian failure（POF）, with an increasingly higher and higher incidence, has become a serious disease which threatens female health in recent years. Many scholars have studied the etiology of it and found that the cause of this disease is multifaceted： genetic defects, hormone and its receptor defects, metabolic disorders and autoimmune disorders can all account for this disease. In addition, some artificial mechanical damage can also induce POF, but the exact mechanism is still unknown. No matter what cause above is the culprit, apoptosis of the granulosa cells concomitantly is widespread in the study, which shows it showed a direct relationship with POF. In this paper, current research progress of granulosa cells＇ apoptosis in POF will be reviewed and a mechanism of granulosa cells＇ apoptosis causing POF will be proposed, which aims to provide a reference for future research.

关 键 词：卵巢早衰 细胞凋亡 卵巢颗粒细胞 颗粒细胞 免疫调控 

分 类 号：R271.11[医药卫生—中医妇科学]