尿α1微球蛋白检测在继发性肾病中的临床意义  

CLINICAL VALUE OF URINARY α1 MICROGLOBULIN DETECTION IN SECONDARY KIDNEY DISEASE

作　　者：颜景春 赵静[2] 高福佳[3] 李盖[4] 朱丽华[5] 

机构地区：[1]河北省唐山市中医医院放射科,063000 [2]唐山职业技术学院临床医学系内科 [3]河北联合大学公共卫生学院 [4]河北联合大学附属医院放射科 [5]河北联合大学基础医学院

出　　处：《中国煤炭工业医学杂志》2014年第6期861-863,共3页Chinese Journal of Coal Industry Medicine

基　　金：河北省科学技术厅项目(132777138;10276158)

摘　　要：目的探讨尿α1微球蛋白(α1-MG)检测在继发性肾病早期诊断中的应用价值。方法采用前瞻性病例对照方法收集该院内科收治的糖尿病性肾病、高血压性肾病及系统性红斑狼疮性肾病患者共计203例,与正常对照组(80例),检测尿α1-MG、尿β2微球蛋白(β2-MG)及尿白蛋白(ALb)结果进行比较。结果患者的尿α1-MG检测结果均高于正常对照组,差异有统计学意义(P<0.01),并且尿α1-MG异常结果的出现明显早于其他微量蛋白。结论尿α1-MG检测对多种继发性肾病的早期诊断及临床观察具有重要的应用价值。Abstact Objective To investigate the value of urinary α1 microglobulin （α1 - MG） detection in the early diagnosis of secondary kidney disease. Methods A casecontrol method was used to collect 203 cases in the hospital, including intermal medicine treaated diabetic kidney disease, hypertension nephropathy and systemic lupus with lupus nephropathy patients, and normal control group （80 cases）, the nrinary α1 microglobulin urinary β2 microglobulin （β2 - MG） and urinary albumin（ ALb） were detected and compared between the two groups. Results The patient＇s urinary α1 - MG test results were higher than those in normal control group, the difference was statistically significant（P〈0. 05）, and abnormal urinary α1- MG results appeared significantly earlier than other microglobulin. Conclusion The detection of urinary α1 - MGhas an important application value for a variety of secondary kedney disease early diagnosis and clinical observation. Key words Urinary α1 microglobulin; Secondary kidney disease; Early diagnosis

关 键 词：尿Α1微球蛋白 继发性肾病 早期诊断 

分 类 号：R692[医药卫生—泌尿科学]