TEAD1在小鼠围着床期子宫中的表达研究  

Expression of TEAD1 in endometrium of mice during peri-implantation period

作　　者：倪华[1] 贲文锐[1] 李文萍[1] 李瑞婷[1] 靳方圆[1] 

机构地区：[1]东北农业大学生命科学学院,哈尔滨150030

出　　处：《东北农业大学学报》2014年第6期97-102,共6页Journal of Northeast Agricultural University

基　　金：国家自然科学基金(30500361)

摘　　要：采用Real-time PCR和原位杂交检测TEAD1在围着床期小鼠子宫及人工诱导蜕膜化组织中的表达情况。Real-time PCR结果显示，在妊娠1~8 d的小鼠子宫中，TEAD1 mRNA的表达随妊娠天数的增加逐渐增强；原位杂交结果显示，TEAD1 mRNA强表达于5~8 d小鼠子宫蜕膜细胞及胚胎上，TEAD1 mRNA强表达于人工诱导蜕膜化组织中。推测TEAD1参与调节子宫基质蜕膜化过程，在胚胎着床过程发挥重要作用。Real-time PCR and in situ hybridization were used to detect the expresstion of TEAD1 in peri-implantation uterus of mice and in artificial decidual cells. Real-time PCR results showed that the expression level of TEAD1 mRNA was gradual y increased in pregnant mice 1-8 d uterus; in situ hybridization showed that, TEAD1 strongly expressed in uterine decidual cells and embryos from pregnant 5-8 d and artificial decidual cells. Inferred TEAD1 might be involved in regulating uterine stromal decidualization and play an important role in embryo implantation process.

关 键 词：TEAD1 胚胎着床 蜕膜化 小鼠 

分 类 号：Q26[生物学—细胞生物学]