先兆早产的危险因素及预防策略  

Risk factors and preventive strategies of threatened premature labor

作　　者：陈惠容[1] 

机构地区：[1]四川省峨眉山市人民医院,614200

出　　处：《职业与健康》2014年第13期1880-1882,共3页Occupation and Health

摘　　要：目的研究先兆早产的危险因素及预防策略。方法将峨眉山市人民医院2012年1月—2013年1月收治入院的70例先兆早产孕妇作为研究组,另取70例正常孕妇作为对照组,比较2组孕妇体内血镁、血清白细胞介素6(IL-6)含量及宫颈长度;记录比较2组孕妇体内胎儿纤维连结蛋白(fFN)及DNA水平。结果先兆早产孕妇中,发病率最高的是妊娠高血压,占51.43%;其次为宫颈功能损伤、子宫肌瘤以及低血镁症。先兆早产孕妇体内血镁水平及宫颈长度明显低于正常孕妇;IL-6高于正常孕妇;2组孕妇上述指标比较,差异有统计学意义(t=11.264,40.355,12.136,均P=0.000);先兆早产孕妇宫颈分泌物内胎儿fFN含量和外周血内胎儿DNA水平均明显高于正常孕妇,2组上述指标差异有统计学意义(t=36.475,54.200,均P=0.000)。结论先兆早产与产妇自身疾病有关,体内血镁、IL-6含量、宫颈长度的变化以及胎儿fFN及DNA水平的改变均易引起先兆早产,应及早预防。[ Objective] To study the risk factors and preventive strategies of threatened premature labor. [ Methods ] From January 2012 to January 2013, 70 pregnant women of threatened premature labor in our hospital were as research group, 70 cases of normal pregnant women were as control group. The blood magnesium, content of serum interleukin and cervical length of pregnant women in two groups were compared, the fetal fiber link protein and DNA levels of pregnant women in two groups were recorded and compared. [ Results] Among pregnant women of threatened premature labor, the incidence of gestational hypertension was the highest （ 51.43 % ） , followed by cervical function damage, uterine fibroids and disease of low blood magnesium. The blood magnesium level and cervical length of pregnant women of threatened premature labor were significantly lower and the concentration of serum interleukin was higher than that of normal pregnant women. The differences of the above indexes in two groups were statistically significant （ t = 11. 2637, 40.3550, 11. 2637 ; P = 0.0000 ）. The content of fetal fiber link protein in cervical secretion and DNA level in the peripheral blood of pregnant women of threatened premature labor were higher than that of normal pregnant women, and the differences were statistically significant （ t = 36.4746, 54.200 ; P = 0.000 ）. [ Conclusion ] Threatened premature labor is associated with maternal disease. The changes of blood magnesium, the content of serum interleukins, cervical length, fetal fiber link protein and DNA level axe easy to cause threatened premature labor, it should be prevented as soon as possible.

关 键 词：先兆早产 危险因素 预防策略 

分 类 号：R714[医药卫生—妇产科学]