重组人干扰素a-2b不同用法治疗慢性乙型肝炎疗效分析  

Analysis of curative effect of chronic hepatitis B recombinant human interferon a-2b treatment for different usage

作　　者：黄肇权 

机构地区：[1]广东省云浮市人民医院,云浮527300

出　　处：《北方药学》2014年第7期98-98,61,共2页Journal of North Pharmacy

摘　　要：目的:探讨重组人干扰素a-2b不同用法治疗慢性乙型肝炎的临床效果。方法:选择我院70例慢性乙型肝炎患者,随机分为观察组和对照组。观察组给予重组人干扰素a-2b,疗程为12个月。对照组给予重组人干扰素a-2b,疗程为6个月。观察两组ALT复常率、HBeAg转阴率及HBeAg/抗HBe血清转换率改变情况。结果:观察组随访12个月的ALT复常率高于对照组,差异有统计学意义(P<0.05)。观察组治疗结束时、随访6个月、随访12个月的HBeAg转阴率、HBeAg/抗HBe血清转换率分别与对照组比较,差异有统计学意义(P<0.05)。结论:重组人干扰素a-2b长疗程治疗慢性乙型肝炎临床效果显著,值得借鉴。Objective ：To explore the clinical effect of different usage of recombinant human interferon a-2b on chronic hepatitis B. Methods： 70 cases with chronic hepatitis B patients and randomly divided into observation group and control group. The observation group was given recombinant human interferon a-2b,the coures was 12 months. The control group received recombinant human interferon a-2b, the course 6 months. the recovery rate of ALT, HBeAg negative conversion rate and HBeAg / anti HBe serum conversion rate were observed in the two groups . Results：The recovery rate of ALT in the observation group after follow-up of 12hours was higher than that in the control group, the difference was statistically significant（P〈0.05）. HBeAg negative conversion rate of HBeAg/ anti HBe seroconversion rates in the observation group at the end of treatment, 6 months of follow-up, 12 months of follow-up were compared with those in the control group, the difference was statistically significant （P〈0.05）. Conclusion：The long course treatment of recombinant human interferon a-2b on chronic hepatitis B has significant effect , the therapy is worthy of reference.

关 键 词：慢性乙型肝炎 重组人干扰素A-2B 

分 类 号：R512.62[医药卫生—内科学]