高血压患者动脉僵硬度与血脂的相关性研究  

Relationship between Arterial Stiffness and Plasma Lipids in Hypertensive Patients

作　　者：王宏宇[1] 刘金波[1] 赵红薇[1] 赵旭静[1] 李丽红[1] 宋月洁[1] 商广芸[1] 

机构地区：[1]北京大学首钢医院血管医学中心,北京市100144

出　　处：《中国全科医学》2014年第18期2070-2073,共4页Chinese General Practice

基　　金：北京市卫生局首都卫生发展科研专项(首发2011-4026-02);北京大学首钢医院院内基金(2010-Y002;2012Y04);首钢总公司科研项目(2013科管20-1)

摘　　要：目的探讨高血压患者动脉僵硬度与血脂的相关性。方法选取北京大学首钢医院血管医学中心2013年度住院高血压患者140例(高血压组)和同期体检健康者402例(对照组)。比较两组受检者的年龄、性别构成、体质指数(BMI)、收缩压、舒张压、脉压、平均血压、心率、空腹血糖(FBG)、肌酐(Cr)、尿酸(UA)、血脂〔总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)〕水平及颈-股动脉脉搏波传导速度(CF-PWV)。结果高血压组患者的年龄、男性比例、BMI、血压、CF-PWV及FBG、Cr、UA、TG水平均高于对照组(P<0.05),而HDL-C水平低于对照组(P<0.05)。Spearman相关分析显示,在全部受检者中,CF-PWV与年龄、BMI、FBG、UA、TC、TG呈正相关(r值分别为0.580、0.122、0.230、0.209、0.106、0.228,均P<0.05),与HDL-C呈负相关(r=-0.195,P<0.05)。进一步校正年龄、性别、血压后,CF-PWV仍与TG呈正相关(r=0.160,P<0.05),与HDL-C呈负相关(r=-0.153,P<0.05)。组内分析结果显示:对照组中,CF-PWV与TC、TG、LDL-C呈正相关(r值分别为0.173、0.267和0.116,均P<0.05),与HDL-C呈负相关(r=-0.137,P<0.05);高血压组中,CF-PWV与TC、TG、HDL-C、LDL-C无线性相关性(P>0.05)。多元线性逐步回归分析显示,在全部受检者中,年龄、脉压、心率、Cr、TG、HDL-C与CF-PWV存在回归关系(β值分别为0.442、0.181、0.072、0.166、0.118和-0.112,均P<0.05);高血压组中,年龄、心率、HDL-C与CF-PWV存在回归关系(β值分别为0.564、0.206和-0.189,均P<0.05)。结论高血压患者动脉僵硬度升高,并且存在血脂紊乱,如TG水平升高,HDL-C水平下降;高血压患者动脉僵硬度与HDL-C有一定的相关性。Objective To investigate the relationship between arterial stiffness and plasma lipids in hypertension patients. Methods A total of 140 hypertensive patients were selected as hypertension group and 402 healthy examinees were selected as control group in department of vascular medicine of Peking University Shougang Hospital in 2013. The age,gender composition,body mass index( BMI),systolic blood pressure,diastolic blood pressure,pulse pressure,mean blood pressure,heart rate,fast blood glucose( FBG),Cr,UA,plasma lipids( TC,TG,HDL-C,LDL-C)and CF-PWV were compared between two groups. Results The age,male composition,BMI,blood pressure,CF-PWV,levels of FBG,Cr,UA and TG in hypertension group were significantly higher than those in control group(all P〈0. 05). Level of HDL-C in hypertension group was significantly lower than that in control group(P〈0. 05). According to results of Spearman correlation analysis,CF-PWV was positively correlated with age,BMI,FBG,levels of UA,TC and TG in the entire study group( rage =0. 580,rBMI =0. 122,rFBG =0. 230,rUA =0. 209,rTC =0. 106,rTG =0. 228,respectively,all P〈0. 05),and was negatively correlated with HDL-C level in the entire group(r= -0. 195,P〈0. 05). After adjusting for age,gender and blood pressure,CF-PWV was still positively correlated with TG level(r=0. 160,P〈0. 05),and was still negatively correlated with HDL-C level(r=-0. 153,P〈0. 05). Intra-group comparison results indicated that CF-PWV was positively correlated with levels of TC,TG and LDL-C in control group(rTC =0. 173,rTG =0. 267,rLDL-C =0. 116,all P〈0. 05),and was negatively correlated with HDL-C level in control group(r= -0. 137,P〈0. 05). There was no significant linear correlation between CF-PWV and levels of TC,TG,HDL-C,LDL-C in hypertension group(P〈0. 05). Multiple linear regression analysis results showed that age,pulse pressure,heart rate,levels of Cr,TG and HDL-C were independently associated with CF-PWV in the entire group(βage =0. 442,βpulse pres ure =0. 181,βheart rate =0. 072,βCr =0. 16

关 键 词：高血压 脉搏波传导速度 脂蛋白类 HDL 

分 类 号：R544.1[医药卫生—心血管疾病]