3,5-二硝基苯甲酸钐与1,10-邻菲罗啉配合物的合成、性能及与小牛胸腺DNA作用研究  

Synthesis and Properties of Samarium Complex with 3,5-Dinitrobenzoic Acid Ligand and 1,10-Phenanthroline and Its Interaction with Ct-DNA

作　　者：董春华[1] 任宁[1] 郝鹃鹃 马小红[1] 刘诚[1] 

机构地区：[1]邯郸学院化学系邯郸市有机小分子材料重点实验室,河北邯郸056005

出　　处：《化学试剂》2014年第7期606-608,645,共4页Chemical Reagents

基　　金：河北省高等学校科学技术研究资助项目(Z2012-060);邯郸市有机小分子材料重点实验室资助项目(201209)

摘　　要：以3,5-二硝基苯甲酸(HL)和1,10-邻菲罗啉(Phen)为配体,采用溶液合成法合成了一种钐配合物。通过元素分析、配位滴定、摩尔电导率、红外光谱和紫外光谱法确定了配合物的组成为Sm(L)3phen。利用热分析、电化学手段对配合物的热稳定性、电化学性能进行了分析。应用粘度法对配合物与小牛胸腺DNA的相互作用进行了研究。结果表明,钐配合物和DNA相互作用是插入模式。Samarium complex based on 3, 5-dinitrobenzoie acid and 1,10-phenanthroline was synthesized by the solution synthetic method. The composition of the title complex was confirmed to be Sm （L） 3 phen （ HL = 3,5-dinitrobenzoic acid ; phen = 1,10-phenanthroline） by means of elemental analysis, coordination titration,molar conduetivity,IR and UV spectra. The properties of the title complex were investigated by means of thermal analysis and electrochemical method. The interaction between complex and Ct-DNA was investigated by vis- cometry. The results showed that the binding mode of the complex with Ct-DNA was intercalation.

关 键 词：稀土 配合物 3 5-二硝基苯甲酸 1 10-邻菲罗啉 DNA 

分 类 号：O614[理学—无机化学]