大鼠在体肠循环结合颈动脉取血研究非诺贝特纳米混悬剂的体内吸收  

Studies on the in vivo absorption of Fenofibrate Nanosuspension by in situintestinal loop combinated with carotid blood sampling in rats

作　　者：王栋[1] 王永禄[1] 叶雯[1] 吕贝贝[1] 韩杰[1] 高天婴 李学明[1] 

机构地区：[1]南京工业大学药学院,南京211816

出　　处：《西北药学杂志》2014年第4期398-402,共5页Northwest Pharmaceutical Journal

基　　金：江苏省政府留学奖学金(2013年);江苏省博士后科研资助计划(编号:1301012A)

摘　　要：目的考察非诺贝特纳米混悬剂在大鼠小肠内的吸收动力学及药动学过程。方法采用大鼠在体肠道灌流结合颈动脉取血实验考察非诺贝特纳米混悬剂的体内吸收情况。结果非诺贝特纳米混悬剂在大鼠体内的血药质量浓度y与肠腔中药物累计减少量x的关系为:y=7×10-5 x+0.521 9,r=0.993 6。结论非诺贝特纳米混悬剂在体肠吸收较好,动物实验体内药动学特性符合一室模型。血药质量浓度和肠腔内药物减少量的相关性良好。Objective To investigate the absorption kinetics of Fenofibrate Nanosuspension in rat intestine.Methods The intestine of rats was cannulated of in siturecirculation and the blood samples were taken from the carotid.The concentration of fenofibric acid in the plasma of rats was determined by HPLC.Results The concentration of fenofibrate in the plasma was correlated with the reducing amount of fenofibrate in the intestine.Conclusion Fenofibrate Nanosuspension could be well absorbed in the whole intestinal segments.The absorption rate of Fenofibrate Nanosuspension in the rat intestine was the first order process with the passive diffusion mechanism.

关 键 词：非诺贝特纳米混悬剂 在体肠吸收 药动学 

分 类 号：R945[医药卫生—微生物与生化药学]