P糖蛋白在细胞膜的定位和功能研究进展  

Research progress on the location and function of P-glycoprotein in cell membrane

作　　者：马园园[1] 颜天华[1] 程涛[2] 刘雯清[2] 曹永兵[2,3] 

机构地区：[1]中国药科大学,南京211198 [2]福建中医药大学,福州350112 [3]第二军医大学,上海200433

出　　处：《西北药学杂志》2014年第4期439-440,F0003,F0004,共4页Northwest Pharmaceutical Journal

基　　金：上海市自然科学基金面上项目(编号:12ZR1437700)

摘　　要：目的综述P糖蛋白与细胞膜脂质的相互作用,为找到抗耐药剂提供有力的帮助。方法检索细胞膜上的脂质(胆固醇、磷脂和糖脂等)以及微区域脂筏和P糖蛋白关系的研究进展。结果 P糖蛋白属于跨膜蛋白,在所有的膜蛋白中,P糖蛋白是对所处的脂质环境最敏感的膜蛋白之一,与细胞膜脂质有密切关系。结论 P糖蛋白是引起肿瘤多药耐药的重要原因之一,细胞膜上的脂质能够影响P糖蛋白的活性和表达,同时P糖蛋白也可以影响脂质的合成,阐明二者的关系能为找到耐药逆转剂提供强有力的帮助。Objective To review the interaction between P-glycoprotein（P-gp）and plasmalemma lipids,and to provide base for finding reversal agents for drug resistance.Method The literatures regarding to the relationships between plasmalemma lipids（cholesterol,phospholipids and glycolipids,etc）,lipid raft and P-gp were retrieved.Result P-gp is one of the most sensitive transmembrane proteins to plasmalemma lipids surroundings and has close relationships with plasmalemma lipids.Conclusion Research indicates that P-gp is one of the most important reasons caused cancer multidrug resistance,and plasmalemma lipids can affect the activity and expression of P-gp while P-gp can influence lipids synthesis.Making their relationships clear can help us to discover reversal agents.

关 键 词：P糖蛋白 多药耐药 脂筏 细胞膜脂质 

分 类 号：R977.6[医药卫生—药品]