氰氟虫腙的合成工艺优化  

Optimized Synthesis of Metafl umizone

作　　者：李爱军[1] 李仁红[1] 靳淑委[2] 

机构地区：[1]河北科技大学化学与制药工程学院,石家庄050018 [2]石家庄科技信息职业学院医药化工系,石家庄050091

出　　处：《农药》2014年第7期482-484,共3页Agrochemicals

摘　　要：[目的]氰氟虫腙是一种新型的缩氨基脲类杀虫剂,对其合成工艺进行优化改进。[方法]以对甲基苯甲腈为原料,经C-酰化、缩合、胺解3步反应合成氰氟虫腙。[结果]在优化的反应条件下,反应总收率72.0%(以对甲基苯甲腈计),含量为99.1%(97.6%E,1.5%Z)。[结论]该工艺收率高、操作简便、反式异构体含量高,适合工业化生产。[Aims] Metaflunizone is a new semicarbazone insecticide, the synthetic process was optimized and improved in this paper. [Methods] Metaflunizone was synthesized from p-tolunitrile via carbon acylated, condensation and amidolysis. [Results] Under the optimal condition, the total yield was 72.0% based on p-tolunitrile and the purity was 99.1%（97.6% E, 1.5% Z）. [Conclusions] The synthetic process has some advantages of high yield, simple operation, high purity E-ratio and is suitable for industrial production.

关 键 词：杀虫剂 氰氟虫腙 合成 

分 类 号：TQ453[化学工程—农药化工]