50例行PESA的无精子症患者血清抑制素B水平分析  

ANALYSIS OF SERUM INHIBIN B LEVELS IN 50 PATIENTS WITH AZOOSPERMIA AFTER PERFORMED PERCUTANEOUS EPIDIDYMAL SPERM ASPIRATION

作　　者：车与睿 

机构地区：[1]青海省妇幼保健院不孕症专科

出　　处：《青海医学院学报》2014年第2期136-138,共3页Journal of Qinghai Medical College

摘　　要：目的比较分析梗阻性无精子症(OA)与非梗阻性无精子症(NOA)患者的血清抑制素B水平,了解血清抑制素B是否对经皮附睾抽吸术(PESA)成功取得精子具有预测作用。方法利用酶联免疫吸附测定法(ELISA)检测OA、NOA患者血清抑制素B含量,同时行经皮附睾精子抽吸术(PESA)进行诊断性穿刺。结果 33例OA患者血清抑制素B平均水平(包括18例CBAVD患者)为(103.10±5.15)pg/mL,17例NOA患者为(40.32±8.40)pg/mL,两者间存在显著差异(P<0.001);PESA取得精子的浓度与血清抑制素B水平正相关(r=0.584,P<0.001)。结论血清抑制素B可以辅助鉴别OA、NOA,也可用于预测PESA能否成功取得精子以及取得精子浓度。Objective Analysis of serum Inhibin B levels in obstructive azoospermia and non - obstructive azoospermia patients and evaluate whether serum inhibin B level can predict the outcome of percutaneous epididymal sperm aspiration（PESA）. Methods Serum levels of inhibin B of 50 azoospermia patients were detected using enzyme - linked immunosorbent assay （ELISA） and all of them were performed percutaneous epididymal sperm aspi- ration for diagnostic puncture. Results There were 33 patients with obstructive azoospermia （ 18 patients with congen- ital bilateral absence of the vas deferens）and 17 patients with non -obstructive azoospermia in 50 patients. There was a significant difference between the obstructive azoospermia group （ 103.10 ± 5.15 ） pg/ml and the non - obstructive azoospermia group（40.32± 8.40）pg/ml,P 〈 0. 001. There was a significant positive correlation between male serum inhibin B levels and sperm concentration in epididymis liquid by PESA（ r = 0. 584, P 〈 0. 001 ）. Conclusions Serum inhibin B may be a good biomarker to identify obstructive and non - obstructive azoospermia and also can predict the outcome of PESA as a diagnostic tool in patients with azoospermia.

关 键 词：血清抑制素B 酶联免疫吸附法 经皮附睾精子抽吸术 

分 类 号：R446[医药卫生—诊断学]