牙周炎的血清学炎性因子水平与冠心病的关系  

Serum inflammatory cytokine levels in periodontitis and its related with coronary heart disease

作　　者：张继东[1] 宋宇 

机构地区：[1]青岛大学医学院附属医院心内科,山东青岛266071 [2]青岛市口腔医院

出　　处：《心血管康复医学杂志》2014年第3期250-253,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:通过检测血清炎性因子水平的变化来探讨牙周炎与冠心病(CHD)之间的相互关系。方法:选择我院CHD患者197例作为研究对象,其中CHD+牙周炎组123例、单纯CHD组39例、单纯牙周炎组35例,另外选择健康者(45例)为健康对照组。检测各组肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、血清淀粉样A蛋白(SAA)、超敏C反应蛋白(hsCRP)的含量及血浆纤维蛋白原(Fg)含量,比较4组间各炎性因子水平的差异。结果:与健康对照组比较,CHD+牙周炎组上述炎性因子均显著升高(P均<0.01),与CHD组或牙周炎组比较,CHD+牙周炎组hsCRP[(6.52±2.03)mg/L、(4.34±1.76)mg/L比(9.21±2.65)mg/L]、IL-6[(65.32±21.01)ng/L、(65.12±12.34)ng/L比(85.76±25.96)ng/L]、TNF-α[(9.75±3.74)ng/L、(9.34±4.55)ng/L比(13.46±8.12)ng/L],SAA[(2.25±1.2)pg/ml,(2.22±1.02)pg/ml比(2.85±1.45)pg/ml]水平明显升高(P均<0.05);CHD组与牙周炎组比较血清炎性因子均无显著差异(P均>0.05)。结论:牙周炎的血清炎性因子水平显著升高,与冠心病有一定关系。Objective：To explore the relationship between periodontitis and coronary heart disease （CHD）by measuring changes of serum inflammatory cytokine levels.Methods：A total of 197 patients from our hospital were enrolled,including CHD ＋ periodontitis group （123 cases）,pure CHD group （CHD group,39 cases）and pure periodontitis group （periodontitis group,35 cases）.Another 45 healthy subjects were enrolled as healthy control group. Concentrations of tumor necrosis factor-α（TNF-α）,interleukin-6 （IL-6）,serum amyloid-a （SAA）,high sensitive C reactive protein （hsCRP）and plasma fibrinogen （Fg）were measured in all groups,and levels of above inflammatory cytokines were compared among four groups.Results：Compared with healthy control group,there were significant rise in levels of above inflammatory cytokines in CHD ＋ periodontitis group （P〈0.01 all）,Compared with CHD group or periodontitis group,there were significant rise in levels of hsCRP [（6.52±2.03）mg/L, （4.34±1.76）mg/L vs.（9.21±2.65）mg/L],IL-6 [（65.32±21.01）ng/L,（65.12±12.34）ng/L vs.（85.76± 25.96）ng/L]and TNF-α[（9.75±3.74）ng/L,（9.34±4.55）ng/L vs.（13.46±8.12）ng/L],SAA [（2.25±1.2） pg/ml,（2.22 ±1.02）pg/ml vs. （2.85±1.45）pg/ml],P〈0.05 all in CHD ＋ periodontitis group;there were no significant difference in all serum inflammatory cytokine levels between CHD group and periodontitis group （P＆gt;0.05 all）.Conclusion：Serum inflammatory cytokine levels significant rise in palients with periodontitis,it is related with coronary heart disease.

关 键 词：牙周炎 动脉硬化 冠状动脉疾病 

分 类 号：R541.409[医药卫生—心血管疾病]