阿托伐他汀治疗老年轻中度高血压患者的效果  

Therapeutic effect of atorvastatin on aged patients with mild to moderate hypertension

作　　者：韩冷[1] 刘波[1] 曹东来[1] 何俊[1] 倪杰[1] 

机构地区：[1]常熟市第一人民医院心内科,江苏常熟215500

出　　处：《心血管康复医学杂志》2014年第3期309-311,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨阿托伐他汀对老年轻中度高血压患者的疗效。方法:2011年7月至2013年7月我院收治的427例轻中度老年高血压患者,按就诊单双号随机分为常规治疗组(210例)和阿托伐他汀组(217例,常规治疗基础上加服阿托伐他汀),连续治疗24个月,比较两组血压、高敏C反应蛋白质(hsCRP)的变化及治疗期间的不良反应。结果:与常规治疗组比较,阿托伐他汀组血压的长期控制(24个月)总有效率显著提高(76.8%比85.9%),血压显著下降[(145.3±10.1/88.6±6.7)mmHg比(136.9±6.8/83.0±5.2)mmHg],hsCRP水平显著降低[(2.02±0.29)mg/L比(1.60±0.18)mg/L](P<0.05或<0.01),两组治疗期间不良反应没有明显差异(P>0.05)。结论:阿托伐他汀和抗高血压药物联合应用可以更好地控制血压,降低炎症反应,适合老年高血压患者长期应用。Objective：To explore therapeutic effect of atorvastatin on aged patients with mild to moderate hypertension.Methods：A total of 427 aged patients with mild to moderate hypertension treated in our hospital from Jul 2011 to Jul 2013 were randomly divided into routine treatment group （n=210）and atorvastatin group （n=217,received atorvastatin additionally based on routine treatment）according to number table.All patients were treated with a continuous 24 months.Therapeutic effect of controlling blood pressure,changes of blood pressure level and high sensitive C reactive protein （hsCRP）level and occurrence of adverse reactions during treatment were compared between two groups.Results：Compared with routine treatment group,there was significant rise in total effective rate of long-term （24 months）controlling blood pressure （76.8% vs.85.9%）,and significant reductions in blood pressure [（145.3±10.1/88.6±6.7）mmHg vs.（136.9±6.8/83.0±5.2）mmHg]and hsCRP [（2.02±0.29）mg/L vs. （1.60±0.18）mg/L]level in atorvastatin group,P〈0.05 or 〈0.01. There was no significant difference in incidence rate of adverse reactions during treatment between two groups （P〉0.05）.Conclusion：Atorvastatin combined antihypertensive drugs can well control blood pressure and reduce inflammatory reactions,which is suitable for long term use in aged patients with hypertension.

关 键 词：阿托伐他汀 高血压 老年 

分 类 号：R544.1[医药卫生—心血管疾病]