54例危重病患者sTREM-1与炎症因子表达的相关性及对预后的影响  

Correlation between sTREM-1 and inflammatory factors expression in 54 cases of critical patients and its effect on clinical prognosis

作　　者：关云艳[1] 王倩[1] 吴海荣[1] 罗宇鸿[1] 吴锡平[1] 王亮[1] 肖涛[1] 

机构地区：[1]江苏省无锡市中医医院重症监护病房,214071

出　　处：《重庆医学》2014年第19期2415-2416,2419,共3页Chongqing medicine

基　　金：无锡市卫生局立项课题(ZZD0803)

摘　　要：目的探讨危重病患者可溶性髓样细胞表达的触发受体-1(sTREM-1)与炎症因子表达的相关性及对疾病严重程度的评估作用和预后的影响。方法对入住该院ICU的54例危重病患者分别于第1天采血检测sTREM-1、肿瘤坏死因子-α(TNF-α)、IL-6、IL-10的表达水平,第3天重复检测sTREM-1的表达水平,同时记录急性生理学与慢性健康状况评分(APACHEⅡ评分)及患者28d生存情况。结果危重病患者sTREM-1的表达水平与TNF-α、IL-6的表达水平及APACHEⅡ评分呈正相关(P<0.01),TNF-α、IL-6的表达水平也与APACHEⅡ评分呈正相关,但这两个指标的pearson相关系数明显低于sTREM-1。死亡组中两次的sTREM-1的表达水平均明显高于非死亡组(P<0.05)。结论 sTREM-1的表达水平与炎症反应及疾病严重程度呈正相关,且sTREM-1的表达水平可作为判断预后的指标。Objective To investigate the correlation between sTREM-1 and inflammatory factors expression in critical patients and its effect on severity of disease and clinical prognosis. Methods sTREM-1 ,TNF-α,IL-6 ,IL-10 levels were checked in serum of 54 patients who admitted to intensive care unit（ICU） on the first day and only sTREM-1 was checked again on the third day. At the same time,APACHEN and survival situation in 28 days were recorded. Results sTREM-1 level in critical patients was positive correlated with TNF-α, IL-6 and APACHE Ⅱ （P〈0. 01）. There was positive correlation between APACHE Ⅱ and TNF-α, IL-6, but pearson correlation coefficient between sTREM-1 and APACHE Ⅱ was higher than TNF-α, IL-6. Compared with the survivor group,the concentrations of serum sTREM-1 was significantly higer in non-survivor group on the first day and the third day after entering ICU（P〈0.05）. Conclusion sTREM-1 level is positive correlated with inflammatory reaction and the severity of disease. It also has prognostic value for outcome in patients with critical illness.

关 键 词：危重病 可溶性髓样细胞表达的触发受体-1 炎症因子 预后 

分 类 号：R459.7[医药卫生—急诊医学]